ArticleNeurobiology of disease2011
Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism.
Article in Neurobiology of disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment.Neurotoxicity research · 2021Article
- Irisin and Autophagy: First Update.International journal of molecular sciences · 2020Review
- Type 1 Interleukin-4 Signaling Obliterates Mouse AstrogliaFrontiers in cell and developmental biology · 2020Article
- Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis.Cell death & disease · 2018Article
- Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death.Scientific reports · 2017Article
- Oxymatrine inhibits microglia activation via HSP60-TLR4 signaling.Biomedical reports · 2016Article
- HSP60 mediates the neuroprotective effects of curcumin by suppressing microglial activation.Experimental and therapeutic medicine · 2016Article
- Neuroprotective effect of resveratrol in diabetic cerebral ischemic-reperfused rats through regulation of inflammatory and apoptotic events.Diabetology & metabolic syndrome · 2014Article
- Viral infection, inflammation and schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- Regulation of NADPH oxidase gene expression with PKA and cytokine IL-4 in neurons and microglia.Neurotoxicity research · 2013Article
- Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.Molecular neurodegeneration · 2012Article
- miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production.Immunology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Microglial cells are resident macrophages in the central nervous system (CNS) and become activated in many pathological conditions. Activation of microglial cells results in reactive microgliosis, manifested by an increase in cell number in the affected CNS regions. The control of microgliosis may be important to prevent pathological damage to the brain. The type 2 cytokine IL-4 has been reported to be protective in brain inflammation. However, its effect on microglial cell survival was not well understood. In this study, we report a dual effect of IL-4 on the survival of mouse microglial cells. In a 6h short term culture, IL-4 reduced the death of microglial cells induced by staurosporine. In contrast, in long term treatment (more than 48h), IL-4 increased the apoptotic death of both primary mouse microglial cells and a microglial cell line N9. Mechanistic studies revealed that, in microglial cells, IL-4 increased the levels of cleaved caspase 3 and PARP, which is down-stream of activated caspase 3. In addition, IL-4 down regulated the autophagy and the antiapoptotic protein Bcl-xL in microglial cells. On the other hand, the pre-incubation of microglial cells with IL-4 for 24h, attenuated the cell death induced by the neurotoxic peptide amyloid beta 1-42 (Aβ42). Our observations demonstrate a novel function of IL-4 in regulating the survival of microglial cells, which may have important significance in reduction of undesired inflammatory responses in the CNS.
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