ArticleJournal of biomedical semantics2011
The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside.
Article in Journal of biomedical semantics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Molecular Diagnostics in Heart Failure: From Biomarkers to Personalized Medicine.Diagnostics (Basel, Switzerland) · 2025Review
- Text Snippets to Corroborate Medical Relations: An Unsupervised Approach using a Knowledge Graph and Embeddings.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020Article
- UMLS to DBPedia link discovery through circular resolution.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Agronomic Linked Data (AgroLD): A knowledge-based system to enable integrative biology in agronomy.PloS one · 2018Article
- A path to precision in the ICU.Critical care (London, England) · 2017Review
- Extending XNAT Platform with an Incremental Semantic Framework.Frontiers in neuroinformatics · 2017Article
- Predicate Oriented Pattern Analysis for Biomedical Knowledge Discovery.Intelligent information management · 2016Article
- Article
- An integrated, ontology-driven approach to constructing observational databases for research.Journal of biomedical informatics · 2015Article
- PubChemRDF: towards the semantic annotation of PubChem compound and substance databases.Journal of cheminformatics · 2015Article
- Semantic enrichment of longitudinal clinical study data using the CDISC standards and the semantic statistics vocabularies.Journal of biomedical semantics · 2015Article
- A framework for ontology-based question answering with application to parasite immunology.Journal of biomedical semantics · 2015Article
- Mining Electronic Health Records using Linked Data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015Article
- Towards a foundational representation of potential drug-drug interaction knowledge.CEUR workshop proceedings · 2014Article
- The Semanticscience Integrated Ontology (SIO) for biomedical research and knowledge discovery.Journal of biomedical semantics · 2014Article
- SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques.Journal of biomedical semantics · 2014Article
- Computational framework to support integration of biomolecular and clinical data within a translational approach.BMC bioinformatics · 2013Article
- Extending the "web of drug identity" with knowledge extracted from United States product labels.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2013Article
- The future state of clinical data capture and documentation: a report from AMIA's 2011 Policy Meeting.Journal of the American Medical Informatics Association : JAMIA · 2013Article
- Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis.Journal of biomedical semantics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
Abstract
backgroundTranslational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery.
resultsWe developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action.
conclusionsThis work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine. AVAILABILITY: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.