ArticleBMC musculoskeletal disorders2011
Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Comparing nurse-led and rheumatologist-led care for rheumatoid arthritis patients: a systematic review and meta-analysis of randomized controlled trials.Revista da Escola de Enfermagem da U S P · 2025Pooled it
- Lower extremity osteoarthritis in elderly patients with rheumatoid arthritis: prevalence, radiographic-clinical discordance, and functional impact - a cross-sectional study.Clinical rheumatology · 2026Article
- Predicting the risk of bone erosion in rheumatoid arthritis using a SHAP-based interpretable machine learning model.Clinical rheumatology · 2026Article
- Remote-Customized Telecontrol for Patients with Rheumatoid Arthritis: The iARPlus (Innovative Approach in Rheumatology) Initiative.Journal of personalized medicine · 2025Article
- Multiscale, mechanistic model of Rheumatoid Arthritis to enable decision making in late stage drug development.NPJ systems biology and applications · 2024Article
- Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP: a nested case-control study.Rheumatology international · 2022Article
- Article
- Measures of Rheumatoid Arthritis Disease Activity.Arthritis care & research · 2020Review
- Disease activity measures at baseline predict structural damage progression: data from the randomized, controlled AMPLE and AVERT trials.Rheumatology (Oxford, England) · 2020Article
- Modified Disease Activity Score at 3 Months Is a Significant Predictor for Rapid Radiographic Progression at 12 Months Compared With Other Measures in Patients With Rheumatoid Arthritis.ACR open rheumatology · 2020Article
- Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis.La Radiologia medica · 2019Review
- Musculoskeletal imaging of the inflammatory and degenerative joints: current status and perspectives.La Radiologia medica · 2019Article
- Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Smartphone APPlications in the clinical care and management of Rheumatic Diseases.Acta bio-medica : Atenei Parmensis · 2018Review
- Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.BMC rheumatology · 2018Article
- Comparison between different disease activity scores in rheumatoid arthritis: an Egyptian multicenter study.Clinical rheumatology · 2017Article
- Time-averaged disease activity fits better joint destruction in rheumatoid arthritis.Scientific reports · 2017Article
- Article
- Observational
- Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe main aim of the study was to investigate the relationship between persistent disease activity and radiographic progression of joint damage in early rheumatoid arthritis (ERA).
methodsForty-eight patients with active ERA was assessed every 3 months for disease activity for 3 years. Radiographic damage was measured by the Sharp/van der Heijde method (SHS). The cumulative inflammatory burden was estimated by the time-integrated values (area under the curve-AUC) of Disease Activity Score 28 joint based on C-reactive protein (DAS28-CRP) in rapid progressors versus non-progressors. Bland and Altman's 95% limits of agreement method were used to estimate the smallest detectable difference (SDD) of radiographic progression. The relationship between clinical and laboratory predictors of radiographic progression and their interactions with time was analysed by logistic regression model.
resultsAfter 3-years of follow-up, radiographic progression was observed in 54.2% (95%CI: 39.8% to 67.5%) of patients and SDD was 9.5 for total SHS. The percentage of patients with erosive disease increased from 33.3% at baseline to 76% at 36 months. The total SHS of the progressors worsened from a median (interquartile range) of 18.5 (15-20) at baseline to 38.5 (34-42) after 3 years (p < 0.0001) whereas non-progressors worsened from a median of 14.5 (13-20) at baseline to 22.5 (20-30) after 3 years (p < 0.001). In the regression model, time-integrated values of DAS28-CRP and anti-CCP positivity have the highest positive predictive value for progression (both at level of p < 0.0001). Radiographic progression was also predicted by a positive IgM-RF (p0.0009), and a high baseline joint damage (p = 0.0044).
conclusionsThese data indicate that the level of disease activity, as measured by time-integrated DAS28-CRP, anti-CCP and IgM-RF positivity and a high baseline joint damage, affects subsequent progression of radiographic damage in ERA.
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