ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2011
Twin-singleton differences in neonatal brain structure.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01409746 (Early Brain Development in Twins), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Brain Development in Twins
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Nomograms and Reference Ranges for Intra-Cranial Ventricular Dimensions in Indian Neonates.Indian journal of pediatrics · 2025Article
- Special Issue editorial: Leveraging genetically informative study designs to understand the development and familial transmission of psychopathology.Development and psychopathology · 2022Article
- Individual Variation of Human Cortical Structure Is Established in the First Year of Life.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Twin-singleton developmental study of brain white matter anatomy.Human brain mapping · 2017Article
- Heritability of the limbic networks.Social cognitive and affective neuroscience · 2016Article
- Quantitative tract-based white matter heritability in twin neonates.NeuroImage · 2015Article
- Article
- Prenatal cocaine effects on brain structure in early infancy.NeuroImage · 2014Article
- Putting the 'epi' into epigenetics research in psychiatry.Journal of epidemiology and community health · 2013Article
- Longitudinal development of cortical and subcortical gray matter from birth to 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- Early Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Twin studies suggest that global and regional brain volumes are highly heritable. However, estimates of heritability vary across development. Given that all twin studies are open to the potential criticism of non-generalizability due to differences in intrauterine environment between twins and singletons, these age effects may reflect the influence of perinatal environmental factors, which are unique to twins and which may be especially evident early in life. To address this question, we compared brain volumes and the relationship of brain volumes to gestational age in 136 singletons (67 male, 69 female) and 154 twins (75 male, 79 female; 82 DZ, 72 MZ) who had received high resolution MRI scans of the brain in the first month of life. Intracranial volume, total white matter, and ventricle volumes did not differ between twins and singletons. However, cerebrospinal fluid and frontal white matter volume was greater in twins compared to singletons. While gray matter volumes at MRI did not differ between groups, the slope of the relationship between total and cortical gray matter and gestational age at the MRI scan was steeper in MZ twins compared to DZ twins. Post-hoc analyses suggested that gray matter development is delayed in MZ twins in utero and that they experience 'catch-up' growth in the first month of life. These differences should be taken into account when interpreting and designing studies in the early postnatal period.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.