Evidence map›Paper›PMID 21623481›Full record

ArticleBiofouling2011

Competitive protein adsorption on polysaccharide and hyaluronate modified surfaces.

Michela Ombelli, Lauren Costello, Corinne Postle, Vinod Anantharaman, Qing Cheng Meng, Russell J Composto, David M Eckmann

Open access · greenAbstract read
In one paragraph

Article in Biofouling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michela OmbelliDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lauren Costello
Corinne Postle
Vinod Anantharaman
Qing Cheng Meng
Russell J Composto
David M Eckmann
University of Pennsylvania · US

Funding

INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISMR01HL060230 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ECKMANN, DAVID M · 1999 to 2011
$3.8M
NHLBI NIH HHS R01 HL060230NHLBI NIH HHS R01 HL60230
6 · The paper itself

Abstract

Adsorption of bovine serum albumin (BSA) and fibrinogen (Fg) was measured on six distinct bare and dextran- and hyaluronate-modified silicon surfaces created using two dextran grafting densities and three hyaluronic acid (HA) sodium salts derived from human umbilical cord, rooster comb and Streptococcus zooepidemicus. Film thickness and surface morphology depended on the HA molecular weight and concentration. BSA coverage was enhanced on surfaces in competitive adsorption of BSA:Fg mixtures. Dextranization differentially reduced protein adsorption onto surfaces based on oxidation state. Hyaluronization was demonstrated to provide the greatest resistance to protein coverage, equivalent to that of the most resistant dextranized surface. Resistance to protein adsorption was independent of the type of HA utilized. With changing bulk protein concentration from 20 to 40 μg ml(-1) for each species, Fg coverage on silicon increased by 4x, whereas both BSA and Fg adsorption on dextran and HA were far less dependent on protein bulk concentration.

Indexed as

AdsorptionAnimalsBiocompatible MaterialsCattleChickensComb and WattlesDextransFibrinogenHumansHyaluronic AcidOxidation-ReductionSerum Albumin, BovineSiliconStreptococcus equiSurface PropertiesUmbilical CordBiocompatible MaterialsDextransFibrinogenHyaluronic AcidSerum Albumin, BovineSilicon

Identifiers

PMID21623481
PMCPMC3105331
OpenAlexW2009502887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.