Trial reportThe journal of nutrition, health & aging2011
The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction.
Trial report in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review.Obesity facts · 2017Pooled it
- Trial
- Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial.Nutrition journal · 2015Trial
- Effect of modest caloric restriction on oxidative stress in women, a randomized trial.PloS one · 2012Trial
- Improving metabolic support during normothermicFrontiers in cardiovascular medicine · 2025Review
- Low glycaemic index or low glycaemic load diets for people with overweight or obesity.The Cochrane database of systematic reviews · 2023Review
- Evaluation of lifespan promoting effects of biofortified wheat in Drosophila melanogaster.Experimental gerontology · 2022Article
- Positive Aspects of Oxidative Stress at Different Levels of the Human Body: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Clinical Trials Targeting Aging.Frontiers in aging · 2022Review
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- An optimal glycemic load range is better for reducing obesity and diabetes risk among middle-aged and elderly adults.Nutrition & metabolism · 2021Article
- Preconditioning with Short-term Dietary Restriction Attenuates Cardiac Oxidative Stress and Hypertrophy Induced by Chronic Pressure Overload.Nutrients · 2021Article
- Impact of calorie restriction on energy metabolism in humans.Experimental gerontology · 2020Review
- Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.Nutrients · 2020Review
- Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases.Frontiers in genetics · 2020Review
- Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.Frontiers in cell and developmental biology · 2020Review
- Cellular Oxidative Stress in Pediatric Leukemia and Lymphoma Patients Undergoing Treatment Is Associated with Protein Consumption.Nutrients · 2019Article
- Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects.Molecular metabolism · 2019Article
- Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders.Frontiers in pharmacology · 2019Review
- Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms.Nature reviews. Gastroenterology & hepatology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction (CR) increases longevity in animals. A total of 46 moderately overweight volunteers (BMI: 25-30 kg/m2), ages 20-42 yr were randomized to either high glycemic (HG) or low glycemic (LG) dietary load CR regimen at either 10% (n=12) or 30% (n=34) of basal caloric intake. All food was provided to participants for 6 mo. Overall, after controlling for CR levels and dietary regimen for 6 mo, plasma glutathione peroxidase activity increased (p=0.04) and plasma protein carbonyl levels decreased (p=0.02) and a non-significant decrease in plasma 8-epi-prostaglandin F2α level was observed (p=0.09). No significant change was observed in other plasma antioxidants such as superoxide dismutase and catalase. These findings indicate that short term CR (10% or 30%) in moderately overweight subjects modulates some but not all measures of antioxidant defense and oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.