Trial reportThe journal of nutrition, health & aging2011
Improved diabetes control in the elderly delays global cognitive decline.
Trial report in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Quality improvement strategies for diabetes care: Effects on outcomes for adults living with diabetes.The Cochrane database of systematic reviews · 2023Pooled it
- Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia.The Cochrane database of systematic reviews · 2017 · on this mapPooled it
- Long-term Change in Physiological Markers and Cognitive Performance in Type 2 Diabetes: The Look AHEAD Study.The Journal of clinical endocrinology and metabolism · 2020Trial
- Enhancing Type 2 Diabetes Management Involving Healthcare Professionals in Primary Care.Healthcare (Basel, Switzerland) · 2026Review
- Cognitive benefits of a lifestyle-induced prediabetes remission intervention in Canada.Preventive medicine reports · 2026Article
- A Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals.Journal of the American Geriatrics Society · 2026Article
- Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus.Acta neuropathologica · 2025Article
- Study of cognitive functions and their association with depression in type II diabetes mellitus.Journal of family medicine and primary care · 2024Article
- Diabetes and cognitive function: An evidence-based current perspective.World journal of diabetes · 2023Review
- Article
- Impact of Intensive Glucose Control on Brain Health: Meta-Analysis of Cumulative Data from 16,584 Patients with Type 2 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- High-Normal Adolescent Fasting Plasma Glucose Is Associated With Poorer Midlife Brain Health: Bogalusa Heart Study.The Journal of clinical endocrinology and metabolism · 2019Article
- Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer's Disease.Diabetes care · 2019Article
- Cognitive Dysfunction Among Adults With Type 2 Diabetes Mellitus in Karnataka, India.Ochsner journal · 2019Article
- Article
- HbADiabetologia · 2018 · on this mapArticle
- Article
- The Inclusion of Ethnic Minority Patients and the Role of Language in Telehealth Trials for Type 2 Diabetes: A Systematic Review.Journal of medical Internet research · 2016Article
- Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology.Journal of Alzheimer's disease : JAD · 2016Article
- Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia.Drugs & aging · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo examine whether improved diabetes control is related to better cognitive outcomes.
designRandomized control trial.
settingA randomized trial of telemedicine vs. usual care in elderly persons with type 2 diabetes.
participantsParticipants were 2169 persons 55 years and older with type 2 diabetes from New York City and Upstate New York.
interventionThe diabetes case management intervention was implemented by a diabetes nurse, via a telemedicine unit in the participant's home, and in coordination with the primary care physician. MEASUREMENTS: Hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and low density lipoprotein cholesterol (LDL), were measured at a baseline visit and at up to 5 annual follow-up visits. Global cognition was measured at those visits with the Comprehensive Assessment and Referral Evaluation (CARE).
resultIn mixed models the intervention was related to slower global cognitive decline in the intervention group (p = 0.01). Improvements in HbA1c (p = 0.03), but not SBP or LDL, mediated the effect of the intervention on cognitive decline.
conclusionImproved diabetes control in the elderly following existing guidelines through a telemedicine intervention was associated with less global cognitive decline. The main mediator of this effect seemed to be improvements in HbA1c.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.