ArticleMolecules (Basel, Switzerland)2011
In vitro and in vivo antitumor activity of Scutellaria barbate extract on murine liver cancer.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trial
- Erzhu Jiedu decoction ameliorates liver precancerous lesions in a rat model of liver cancer.Journal of Cancer · 2020Article
- Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects.Biomolecules · 2019Review
- Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action.BMC complementary and alternative medicine · 2017Article
- Scutellaria barbata D. Don extract inhibits the tumor growth through down-regulating of Treg cells and manipulating Th1/Th17 immune response in hepatoma H22-bearing mice.BMC complementary and alternative medicine · 2017Article
- Doxorubicin combined with celecoxib inhibits tumor growth of medullary thyroid carcinoma in xenografted mice.Oncology letters · 2014Article
- Mineral elements and essential oil contents of Scutellaria luteo-caerulea Bornm. & Snit.Avicenna journal of phytomedicine · 2014Article
- Induction of apoptosis by total flavonoids from Scutellaria barbata D. Don in human hepatocarcinoma MHCC97-H cells via the mitochondrial pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don.BMC complementary and alternative medicine · 2013Article
- Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells.Cancer cell international · 2013Article
- Total flavonoids of Scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in vitro.Molecules (Basel, Switzerland) · 2013Article
- Lessons learnt from evidence-based approach of using chinese herbal medicines in liver cancer.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Traditional herbal medicine: a review of potential of inhibitory hepatocellular carcinoma in basic research and clinical trial.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo.Cancer cell international · 2012Article
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9 authors.
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Abstract
In the present study, we investigated the in vitro and in vivo antitumor effects of crude extract of Scutellaria Barbate (CE-SB) on mouse hepatoma H22 cells. The MTT assay was used to determine the growth inhibition of H22 cells in vitro. The in vivo therapeutic effects of CE-SB were determined using H22 tumor bearing mice. Besides, the body weight, tumor weight, thymus index and spleen index of H22 bearing mice were also measured. The tumor inhibitory rate (IR) was calculated according to the mean weight of tumor (MWT). The phagocytotic function of macrophages was examined by observing peritoneal macrophages phagocytize chicken RBC. The results showed that CE-SB could inhibit the growth of hepatoma H22 Cells in vitro and in vivo. Furthermore, CE-SB could improve immune function of H22 tumor bearing mice. Together these results indicate that CE-SB has antitumor activity and seems to be safe and effective for the use of anti-tumor therapy.
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