Trial reportJournal of endocrinological investigation2012
Changes in lifestyle improve body composition, thyroid function, and structure in obese children.
Trial report in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Trial
- Association between childhood obesity and thyroid function: a cross-sectional study in a Chinese population.BMC public health · 2026Article
- Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?Current nutrition reports · 2024Review
- Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019).The Journal of clinical endocrinology and metabolism · 2024Article
- Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review.Frontiers in nutrition · 2022Article
- Basal and longitudinal changes in serum levels of TSH in morbid obese patients experiencing failure or success of dietary treatment.Eating and weight disorders : EWD · 2021Article
- Thyroid Homeostasis After Bariatric Surgery in Obese Cases.Obesity surgery · 2020Article
- The relationship between hyperthyrotropinemia and metabolic and cardiovascular risk factors in a large group of overweight and obese children and adolescents.Journal of endocrinological investigation · 2017Article
- Ultrasound image of the thyroid gland in obese children.Journal of ultrasonography · 2015Review
- Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.Journal of endocrinological investigation · 2014Article
- 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children.European thyroid journal · 2014Article
- Serum-negative autoimmune thyroiditis: what's in a name?Journal of endocrinological investigation · 2014Article
- Is thyroid-stimulating hormone within the normal reference range a risk factor for atherosclerosis in women?Internal and emergency medicine · 2014Article
- Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents.Journal of endocrinological investigation · 2013Article
- Thyroid function and obesity.Journal of clinical research in pediatric endocrinology · 2013Review
- ASSOCIATIONS OF THYROID VOLUME AND FUNCTION WITH CHILDHOOD OBESITY.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Cardiovascular Risk Factors in Children and Adolescents with Subclinical Hypothyroidism.Indian journal of endocrinology and metabolismArticle
- Hypothyroidism and obesity: An intriguing link.Indian journal of endocrinology and metabolismReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in thyroid function and structure have been reported in obesity. Function reverses to normal after weight loss, but nothing is known about structure.
aimTo evaluate the effect of weight loss on thyroid function and structure in obese children. SUBJECTS AND
methodsThe study was conducted in 72 overweight and obese children. Measurement of free T(3) (fT(3)), free T4 (fT(4)), TSH, antithyroid- antibodies and a thyroid ultrasound was performed at the beginning (phase 1) and after a period of 1.8±1.0 yr of lifestyle intervention (phase 2).
resultsHeight SD score (SDS), body mass index SDS, total fat mass did not change from phase 1 to phase 2. Percentage of fat free mass decreased significantly (p<0.05). Waist/height ratio decreased (0.6±0.1 vs 0.5±0.1; p<0.05) as well as waist/hip ratio (0.9±0.1 vs 0.8±0.1; p<0.05). In phase 1, TSH was 2.8±1.7 mU/l; in phase 2, it was 2.2±0.9 mU/l (p<0.05); 17.2% of children showed a TSH level above the normal range (3.6 mU/l) in phase 1, and 6.2% in phase 2 (p<0.05). fT(4) was 10.8±2.2 pg/ml in phase 1 and 10.7±1.9 pg/ml in phase 2. fT(3) was 4.4±1.3 pg/ml (phase 1) and 3.9±1.1 pg/ml (phase 2) (p<0.05). Thyroid volume was -0.5±0.8 SDS (phase 1) and -0.5±1 SDS (phase 2). A non-significant improvement in thyroid structure was observed.
conclusionsIn conclusion, healthier lifestyle improves body composition, thyroid function, and structure.
Indexed as
Identifiers
21623157What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.