ArticleJournal of neural engineering2011
High frequency stimulation abolishes thalamic network oscillations: an electrophysiological and computational analysis.
Article in Journal of neural engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Thalamic Neuromodulation: New Frontiers.Epilepsy currents · 2026Article
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy.PLoS computational biology · 2025Article
- Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022Review
- Optogenetic activation of the reticular nucleus of the thalamus attenuates limbic seizures via inhibition of the midline thalamus.Epilepsia · 2021Article
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- Modulation of Glia-Mediated Processes by Spinal Cord Stimulation in Animal Models of Neuropathic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Abnormal Functional Brain Network in Parkinson's Disease and the Effect of Acute Deep Brain Stimulation.Frontiers in neurology · 2021Article
- Dysfunctional Brain Dynamics of Parkinson's Disease and the Effect of Acute Deep Brain Stimulation.Frontiers in neuroscience · 2021Article
- Glia to neuron ratio in the posterior aspect of the human spinal cord at thoracic segments relevant to spinal cord stimulation.Journal of anatomy · 2019Article
- Electrical Stimulation of C6 Glia-Precursor Cells In Vitro Differentially Modulates Gene Expression Related to Chronic Pain Pathways.Brain sciences · 2019Article
- Deep brain stimulation induces sparse distributions of locally modulated neuronal activity.Scientific reports · 2018Article
- Parkinson's Disease and Its Management: Part 3: Nondopaminergic and Nonpharmacological Treatment Options.P & T : a peer-reviewed journal for formulary management · 2015Article
- Article
- Deep brain stimulation in Parkinson's disease.Translational neurodegeneration · 2013Article
- Computational modeling of epilepsy for an experimental neurologist.Experimental neurology · 2013Review
- Modeling noninvasive neurostimulation in epilepsy as stochastic interference in brain networks.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2013Article
- Modulation of epileptic activity by deep brain stimulation: a model-based study of frequency-dependent effects.Frontiers in computational neuroscience · 2013Article
- The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: an experimental study in the monkey.Translational psychiatry · 2012Article
- Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study.Neuropsychiatric disease and treatment · 2011Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Deep brain stimulation (DBS) of the thalamus has been demonstrated to be effective for the treatment of epilepsy. To investigate the mechanism of action of thalamic DBS, we examined the effects of high frequency stimulation (HFS) on spindle oscillations in thalamic brain slices from ferrets. We recorded intracellular and extracellular electrophysiological activity in the nucleus reticularis thalami (nRt) and in thalamocortical relay (TC) neurons in the lateral geniculate nucleus, stimulated the slice using a concentric bipolar electrode, and recorded the level of glutamate within the slice. HFS (100 Hz) of TC neurons generated excitatory post-synaptic potentials, increased the number of action potentials in both TC and nRt neurons, reduced the input resistance, increased the extracellular glutamate concentration, and abolished spindle wave oscillations. HFS of the nRt also suppressed spindle oscillations. In both locations, HFS was associated with significant and persistent elevation in extracellular glutamate levels and suppressed spindle oscillations for many seconds after the cessation of stimulation. We simulated HFS within a computational model of the thalamic network, and HFS also disrupted spindle wave activity, but the suppression of spindle activity was short-lived. Simulated HFS disrupted spindle activity for prolonged periods of time only after glutamate release and glutamate-mediated activation of a hyperpolarization-activated current (I(h)) was incorporated into the model. Our results suggest that the mechanism of action of thalamic DBS as used in epilepsy may involve the prolonged release of glutamate, which in turn modulates specific ion channels such as I(h), decreases neuronal input resistance, and abolishes thalamic network oscillatory activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.