ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
Diaphragm muscle fiber function and structure in humans with hemidiaphragm paralysis.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation.American journal of physiology. Lung cellular and molecular physiology · 2014Trial
- Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.Journal of cachexia, sarcopenia and muscle · 2025Article
- Intraoperative phrenic nerve stimulation to prevent diaphragm fiber weakness during thoracic surgery.PloS one · 2025Article
- Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity.Frontiers in cellular neuroscience · 2023Article
- The phrenic neuromuscular system.Handbook of clinical neurology · 2022Review
- Structural abnormalities in the human diaphragm in drowning and hanging deaths: preliminary results.Forensic science, medicine, and pathology · 2020Article
- Size and Proportions of Slow-Twitch and Fast-Twitch Muscle Fibers in Human Costal Diaphragm.BioMed research international · 2016Article
- Impact of unilateral denervation on transdiaphragmatic pressure.Respiratory physiology & neurobiology · 2015Article
- The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction.Molecular medicine (Cambridge, Mass.) · 2015Article
- The authors reply.Critical care medicine · 2014Article
- Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.American journal of respiratory and critical care medicine · 2014Article
- Rapid diaphragm atrophy following cervical spinal cord hemisection.Respiratory physiology & neurobiology · 2014Article
- Rebuttal from Scott K. Powers, Ashley J. Smuder, David Fuller and Sanford Levine.The Journal of physiology · 2013Article
- Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.Respiratory physiology & neurobiology · 2012Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies proposed that mechanical inactivity of the human diaphragm during mechanical ventilation rapidly causes diaphragm atrophy and weakness. However, conclusive evidence for the notion that diaphragm weakness is a direct consequence of mechanical inactivity is lacking. To study the effect of hemidiaphragm paralysis on diaphragm muscle fiber function and structure in humans, biopsies were obtained from the paralyzed hemidiaphragm in eight patients with hemidiaphragm paralysis. All patients had unilateral paralysis of known duration, caused by en bloc resection of the phrenic nerve with a tumor. Furthermore, diaphragm biopsies were obtained from three control subjects. The contractile performance of demembranated muscle fibers was determined, as well as fiber ultrastructure and morphology. Finally, expression of E3 ligases and proteasome activity was determined to evaluate activation of the ubiquitin-proteasome pathway. The force-generating capacity, as well as myofibrillar ultrastructure, of diaphragm muscle fibers was preserved up to 8 wk of paralysis. The cross-sectional area of slow fibers was reduced after 2 wk of paralysis; that of fast fibers was preserved up to 8 wk. The expression of the E3 ligases MAFbx and MuRF-1 and proteasome activity was not significantly upregulated in diaphragm fibers following paralysis, not even after 72 and 88 wk of paralysis, at which time marked atrophy of slow and fast diaphragm fibers had occurred. Diaphragm muscle fiber atrophy and weakness following hemidiaphragm paralysis develops slowly and takes months to occur.
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