ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Genomic diversity and adaptive resistance mechanisms inmSystems · 2026Article
- Building a predictive model for polycyclic aromatic hydrocarbon dosimetry in organotypically cultured human bronchial epithelial cells using benzo[Toxicology reports · 2025Article
- Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers.International journal of pharmaceutics · 2023Review
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.Science advances · 2022Article
- Mucus, Microbiomes and Pulmonary Disease.Biomedicines · 2021Review
- Large pH oscillations promote host defense against human airways infection.The Journal of experimental medicine · 2021Article
- The Bactericidal Tandem Drug, AB569: How to Eradicate Antibiotic-Resistant BiofilmFrontiers in microbiology · 2021Review
- Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis.ERJ open research · 2020Article
- Development of an airway mucus defect in the cystic fibrosis rat.JCI insight · 2018Article
- Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens.Nature communications · 2017Article
- Article
- Virulence adaptations ofMicrobiology (Reading, England) · 2016Article
- PATHOPHYSIOLOGIC EVALUATION OF THE TRANSGENIC CFTR "GUT-CORRECTED" PORCINE MODEL OF CYSTIC FIBROSIS.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Acidic pH increases airway surface liquid viscosity in cystic fibrosis.The Journal of clinical investigation · 2016Article
- Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Automated analysis of dynamic Ca2+ signals in image sequences.Journal of visualized experiments : JoVE · 2014Article
- Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography.PloS one · 2013Article
- Cystic fibrosis: a mucosal immunodeficiency syndrome.Nature medicine · 2012Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
To better understand how airways produce thick airway mucus, nonvolatile solids were measured in liquid secreted by bronchi from normal pig, cystic fibrosis (CF) human, and non-CF human lungs. Bronchi were exposed to various secretagogues and anion secretion inhibitors to induce a range of liquid volume secretion rates. In all three groups, the relationship of solids concentration (percent nonvolatile solids) to liquid volume secretion rate was curvilinear, with higher solids concentration associated with lower rates of liquid volume secretion. In contrast, the secretion rates of solids mass and water mass as functions of liquid volume secretion rates exhibited positive linear correlations. The y-intercepts of the solids mass-liquid volume secretion relationships for all three groups were positive, thus accounting for the higher solids concentrations in airway liquid at low rates of secretion. Predictive models derived from the solids mass and water mass linear equations fit the experimental percent solids data for the three groups. The ratio of solids mass secretion to liquid volume secretion was 5.2 and 2.4 times higher for CF bronchi than for pig and non-CF bronchi, respectively. These results indicate that normal pig, non-CF human, and CF human bronchi produce a high-percent-solids mucus (>8%) at low rates of liquid volume secretion (≤1.0 μl·cm(-2)·h(-1)). However, CF bronchi produce mucus with twice the percent solids (~8%) of pig or non-CF human bronchi at liquid volume secretion rates ≥4.0 μl·cm(-2)·h(-1).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.