ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Physical activity-induced myokine responses in major mammalian farm animal species: a mini-review.Frontiers in veterinary science · 2026Review
- Genetic silencing of KChannels (Austin, Tex.) · 2025Article
- Article
- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
- Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet-Fed Female Mice.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells.PloS one · 2015Article
- Identification of genes whose expression is altered by obesity throughout the arterial tree.Physiological genomics · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins.Experimental physiology · 2014Article
- Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs.Metabolism: clinical and experimental · 2013Article
- Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.Physiological genomics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
While the salutary effects of exercise training on conduit artery endothelial cells have been reported in animals and humans with cardiovascular risk factors or disease, whether a healthy endothelium is alterable with exercise training is less certain. The purpose of this study was to evaluate the impact of exercise training on transcriptional profiles in normal endothelial cells using a genome-wide microarray analysis. Brachial and internal mammary endothelial gene expression was compared between a group of healthy pigs that exercise trained for 16-20 wk (n = 8) and a group that remained sedentary (n = 8). We found that a total of 130 genes were upregulated and 84 genes downregulated in brachial artery endothelial cells with exercise training (>1.5-fold and false discovery rate <15%). In contrast, a total of 113 genes were upregulated and 31 genes downregulated in internal mammary artery endothelial cells using the same criteria. Although there was an overlap of 66 genes (59 upregulated and 7 downregulated with exercise training) between the brachial and internal mammary arteries, the identified endothelial gene networks and biological processes influenced by exercise training were distinctly different between the brachial and internal mammary arteries. These data indicate that a healthy endothelium is indeed responsive to exercise training and support the concept that the influence of physical activity on endothelial gene expression is not homogenously distributed throughout the vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.