ArticleJournal of bacteriology2011
Comparative genomic analysis of the hexuronate metabolism genes and their regulation in gammaproteobacteria.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators.Nucleic acids research · 2025Article
- A Novel Lineage of Endosymbiotic Actinomycetales: Genome Reduction and Acquisition of New Functions in Bifidobacteriaceae Associated With Termite Gut Flagellates.Environmental microbiology · 2025Article
- Biosensor development for single-cell detection of glucuronate.Journal of industrial microbiology & biotechnology · 2023Article
- Metabolically-targeted dCas9 expression in bacteria.Nucleic acids research · 2023Article
- Sense and antisense RNA products of theFrontiers in molecular biosciences · 2023Article
- A pathway for chitin oxidation in marine bacteria.Nature communications · 2022Article
- Differential Impact of Hexuronate Regulators ExuR and UxuR on theInternational journal of molecular sciences · 2022Article
- Diet-derived galacturonic acid regulates virulence and intestinal colonization in enterohaemorrhagic Escherichia coli and Citrobacter rodentium.Nature microbiology · 2020Article
- Genomic analyses of Burkholderia cenocepacia reveal multiple species with differential host-adaptation to plants and humans.BMC genomics · 2019Article
- Carbohydrate metabolic systems present on genomic islands are lost and gained in Vibrio parahaemolyticus.BMC microbiology · 2019Article
- Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.Journal of bacteriology · 2019Article
- How Bioinformatic Tools Guide Experiments To Resolve the Chaos of Apparently Unlimited Metabolic Variation.Journal of bacteriology · 2019Article
- Single-target regulators form a minor group of transcription factors in Escherichia coli K-12.Nucleic acids research · 2018Article
- Genome Analysis of Endomicrobium proavitum Suggests Loss and Gain of Relevant Functions during the Evolution of Intracellular Symbionts.Applied and environmental microbiology · 2017Article
- Characterization of Potential Polysaccharide Utilization Systems in the MarineFrontiers in microbiology · 2017Article
- Contribution of the Salmonella enterica KdgR Regulon to Persistence of the Pathogen in Vegetable Soft Rots.Applied and environmental microbiology · 2016Article
- Nitrogen Fixation and Molecular Oxygen: Comparative Genomic Reconstruction of Transcription Regulation in Alphaproteobacteria.Frontiers in microbiology · 2016Article
- Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.Biochemistry · 2015Article
- Comparative genomics and evolution of regulons of the LacI-family transcription factors.Frontiers in microbiology · 2014Article
- RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hexuronate metabolism in Escherichia coli is regulated by two related transcription factors from the FadR subfamily of the GntR family, UxuR and ExuR. UxuR controls the d-glucuronate metabolism, while ExuR represses genes involved in the metabolism of all hexuronates. We use a comparative genomics approach to reconstruct the hexuronate metabolic pathways and transcriptional regulons in gammaproteobacteria. We demonstrate differences in the binding motifs of UxuR and ExuR, identify new candidate members of the UxuR/ExuR regulons, and describe the links between the UxuR/ExuR regulons and the adjacent regulons UidR, KdgR, and YjjM. We provide experimental evidence that two predicted members of the UxuR regulon, yjjM and yjjN, are the subject of complex regulation by this transcription factor in E. coli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.