ArticleJournal of bacteriology2011
Lateral transfer of genes and gene fragments in Staphylococcus extends beyond mobile elements.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Kente: A Graph-based Pangenomic Approach for Horizontal Gene Transfer Detection in Microbiomes.bioRxiv : the preprint server for biology · 2026Article
- SegMantX: A Novel Tool for Detecting DNA Duplications Uncovers Prevalent Duplications in Plasmids.Molecular biology and evolution · 2025Article
- Detecting genetic gain and loss events in terms of protein domain: Method and implementation.Heliyon · 2024Article
- Taxonomic Diversity and Functional Traits of Soil Bacterial Communities under Radioactive Contamination: A Review.Microorganisms · 2024Review
- Molecular identification and whole genome sequence analyses of methicillin-resistant and mastitis-associatedJournal of genomics · 2024Article
- Identification of Putative Vaccine and Drug Targets against the Methicillin-ResistantMolecules (Basel, Switzerland) · 2022Article
- Article
- Characterization of methicillin-resistant3 Biotech · 2020Article
- How enzyme promiscuity and horizontal gene transfer contribute to metabolic innovation.The FEBS journal · 2020Review
- Phylogenomic Analysis Reveals the Evolutionary Route of Resistant Genes in Staphylococcus aureus.Genome biology and evolution · 2019Article
- Antibiotic-resistantSaudi journal of biological sciences · 2019Article
- Hundreds of novel composite genes and chimeric genes with bacterial origins contributed to haloarchaeal evolution.Genome biology · 2018Article
- Antimicrobial susceptibility patterns: a three-year surveillance study in a rehabilitation setting.The Pan African medical journal · 2016Article
- Ecological Overlap and Horizontal Gene Transfer in Staphylococcus aureus and Staphylococcus epidermidis.Genome biology and evolution · 2015Article
- Interactions in the microbiome: communities of organisms and communities of genes.FEMS microbiology reviews · 2014Review
- Clustering evolving proteins into homologous families.BMC bioinformatics · 2013Article
- Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization.Genome research · 2013Article
- Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus.Genome biology · 2012Article
- ANALYSIS OF ALEXANDRIUM TAMARENSE (DINOPHYCEAE) GENES REVEALS THE COMPLEX EVOLUTIONARY HISTORY OF A MICROBIAL EUKARYOTE().Journal of phycology · 2012Article
- Phylogenetic relationships among Staphylococcus species and refinement of cluster groups based on multilocus data.BMC evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widespread presence of antibiotic resistance and virulence among Staphylococcus isolates has been attributed in part to lateral genetic transfer (LGT), but little is known about the broader extent of LGT within this genus. Here we report the first systematic study of the modularity of genetic transfer among 13 Staphylococcus genomes covering four distinct named species. Using a topology-based phylogenetic approach, we found, among 1,354 sets of homologous genes examined, strong evidence of LGT in 368 (27.1%) gene sets, and weaker evidence in another 259 (19.1%). Within-gene and whole-gene transfer contribute almost equally to the topological discordance of these gene sets against a reference phylogeny. Comparing genetic transfer in single-copy and in multicopy gene sets, we observed a higher frequency of LGT in the latter, and a substantial functional bias in cases of whole-gene transfer (little such bias was observed in cases of fragmentary genetic transfer). We found evidence that lateral transfer, particularly of entire genes, impacts not only functions related to antibiotic, drug, and heavy-metal resistance, as well as membrane transport, but also core informational and metabolic functions not associated with mobile elements. Although patterns of sequence similarity support the cohesion of recognized species, LGT within S. aureus appears frequently to disrupt clonal complexes. Our results demonstrate that LGT and gene duplication play important parts in functional innovation in staphylococcal genomes.
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