Evidence map›Paper›PMID 21622645›Full record

ReviewBlood2011

Transcription factor networks in erythroid cell and megakaryocyte development.

Louis C Doré, John D Crispino

Abstract readReview
In one paragraph

Review in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 254 citations in OpenAlex.

  1. Article
  2. Article
  3. Acute-on-chronic liver failure-associated CD45Cellular and molecular life sciences : CMLS · 2026
    Article
  4. Article
  5. ReducedInternational journal of molecular sciences · 2026
    Article
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  9. Review
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  13. Review
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  15. Article
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Louis C DoréDivision of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.
John D Crispino
Northwestern University · US

Funding

CORE: ADMINISTRATIVEP50GM081892 · NIGMS · UNIVERSITY OF CHICAGO · PI WHITE, KEVIN P. · 2008 to 2013
$15.9M
TRAINING PROGRAM IN ONCOGENESIS &DEVELOPMENT BIOLOGYT32CA080621 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EKLUND, ELIZABETH ANN · 2001 to 2018
$4.1M
NCI NIH HHS T32 CA080621NCI NIH HHS T32-CA080621NIGMS NIH HHS GM081892NIGMS NIH HHS P50 GM081892
6 · The paper itself

Abstract

Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.

Indexed as

Erythroid CellsAnimalsCell DifferentiationCell LineageGene Regulatory NetworksHematopoiesisHumansMegakaryocyte-Erythroid Progenitor CellsMegakaryocytesModels, BiologicalTranscription FactorsTranscription Factors

Identifiers

PMID21622645
PMCPMC3138678
OpenAlexW1978031011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.