ArticleThe Journal of biological chemistry2011
Oxygen supply from the bird's eye perspective: globin E is a respiratory protein in the chicken retina.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- The Opto-Respiratory Compromise: Balancing Oxygen Supply and Light Transmittance in the Retina.Physiology (Bethesda, Md.) · 2022Review
- The More, the Merrier? Multiple Myoglobin Genes in Fish Species, Especially in Gray Bichir (Polypterus senegalus) and Reedfish (Erpetoichthys calabaricus).Genome biology and evolution · 2021Article
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020Review
- Origin of complexity in haemoglobin evolution.Nature · 2020Article
- Globin E is a myoglobin-related, respiratory protein highly expressed in lungfish oocytes.Scientific reports · 2019Article
- Distribution of Cytoglobin in the Mouse Brain.Frontiers in neuroanatomy · 2016Article
- Ancient Duplications and Expression Divergence in the Globin Gene Superfamily of Vertebrates: Insights from the Elephant Shark Genome and Transcriptome.Molecular biology and evolution · 2015Article
- The Full Globin Repertoire of Turtles Provides Insights into Vertebrate Globin Evolution and Functions.Genome biology and evolution · 2015Article
- A lab-on-a-chip for hypoxic patch clamp measurements combined with optical tweezers and spectroscopy- first investigations of single biological cells.Biomedical engineering online · 2015Article
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- More than hemoglobin - the unexpected diversity of globins in vertebrate red blood cells.Physiological reports · 2015Article
- The globin gene repertoire of lampreys: convergent evolution of hemoglobin and myoglobin in jawed and jawless vertebrates.Molecular biology and evolution · 2014Article
- Gene duplication, genome duplication, and the functional diversification of vertebrate globins.Molecular phylogenetics and evolution · 2013Review
- Article
- Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates.Molecular biology and evolution · 2012Article
- A membrane-bound vertebrate globin.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The visual process in the vertebrate eye requires high amounts of metabolic energy and thus oxygen. Oxygen supply of the avian retina is a challenging task because birds have large eyes, thick retinae, and high metabolic rates but neither deep retinal nor superficial capillaries. Respiratory proteins such as myoglobin may enhance oxygen supply to certain tissues, and thus the mammalian retina harbors high amounts of neuroglobin. Globin E (GbE) was recently identified as an eye-specific globin of chicken (Gallus gallus). Orthologous GbE genes were found in zebra finch and turkey genomes but appear to be absent in non-avian vertebrate classes. Analyses of globin phylogeny and gene synteny showed an ancient origin of GbE but did not help to assign it to any specific globin type. We show that the photoreceptor cells of the chicken retina have a high level of GbE protein, which accumulates to ∼10 μM in the total eye. Quantitative real-time RT-PCR revealed an ∼50,000-fold higher level of GbE mRNA in the eye than in the brain. Spectroscopic analysis and ligand binding kinetics of recombinant chicken GbE reveal a penta-coordinated globin with an oxygen affinity of P(50) = 5.8 torrs at 25 °C and 15 torrs at 41 °C. Together these data suggest that GbE helps to sustain oxygen supply to the avian retina.
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