ArticleThe Journal of biological chemistry2011
Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- A Dual Effect of Dopamine on Hippocampal LTP and Cognitive Functions in Control and Kindled Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia.BMC psychiatry · 2023Article
- Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications.Molecular psychiatry · 2022Review
- Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal-Striatal-Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia.Frontiers in psychiatry · 2021Article
- SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study.Frontiers in genetics · 2020Article
- Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission.Schizophrenia bulletin · 2019Article
- Fear Memory Recall Potentiates Opiate Reward Sensitivity through Dissociable Dopamine D1 versus D4 Receptor-Dependent Memory Mechanisms in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A reply to 'Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study'.Translational psychiatry · 2016Article
- Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex.The Journal of physiology · 2016Article
- Distinct Physiological Effects of Dopamine D4 Receptors on Prefrontal Cortical Pyramidal Neurons and Fast-Spiking Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals.The Journal of biological chemistry · 2013Article
- Dopamine, cognitive function, and gamma oscillations: role of D4 receptors.Frontiers in cellular neuroscience · 2013Article
- Dopamine D4 receptor transmission in the prefrontal cortex controls the salience of emotional memory via modulation of calcium calmodulin-dependent kinase II.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- CaMKII regulation in information processing and storage.Trends in neurosciences · 2012Review
- Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia.Behavioral and brain functions : BBF · 2012Article
- Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin.The Journal of biological chemistry · 2011Article
- The Dopamine D4 Receptor Regulates Gonadotropin-Releasing Hormone Neuron Excitability in Male Mice.eNeuroArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant dopamine D(4) receptor function has been implicated in mental illnesses, including schizophrenia and attention deficit-hyperactivity disorder. Recently we have found that D(4) receptor exerts an activity-dependent bi-directional regulation of AMPA receptor (AMPAR)-mediated synaptic currents in pyramidal neurons of prefrontal cortex (PFC) via the dual control of calcium/calmodulin kinase II (CaMKII) activity. In this study, we examined the signaling mechanisms downstream of CaMKII that govern the complex effects of D(4) on glutamatergic transmission. We found that in PFC neurons at high activity state, D(4) suppresses AMPAR responses by disrupting the kinesin motor-based transport of GluR2 along microtubules, which was accompanied by the D(4) reduction of microtubule stability via a mechanism dependent on CaMKII inhibition. On the other hand, in PFC neurons at the low activity state, D(4) potentiates AMPAR responses by facilitating synaptic targeting of GluR1 through the scaffold protein SAP97 via a mechanism dependent on CaMKII stimulation. Taken together, these results have identified distinct signaling mechanisms underlying the homeostatic regulation of glutamatergic transmission by D(4) receptors, which may be important for cognitive and emotional processes in which dopamine is involved.
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