ReviewEndocrine reviews2011
Synaptocrine signaling: steroid synthesis and action at the synapse.
Review in Endocrine reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multivariate Models of Animal Sex: Breaking Binaries Leads to a Better Understanding of Ecology and Evolution.Integrative and comparative biology · 2023Pooled it
- Increased functional connectivity with puberty in the mentalising network involved in social emotion processing.Hormones and behavior · 2013Trial
- An Aggressive Interaction Rapidly Increases Brain Androgens in a Male Songbird during the Non-breeding Season.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmental and adult stress: effects of steroids and neurosteroids.Stress (Amsterdam, Netherlands) · 2024Review
- Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans.Frontiers in endocrinology · 2024Review
- Estrogens rapidly shape synaptic and intrinsic properties to regulate the temporal precision of songbird auditory neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatial and temporal specificity of neuroestradiol provision in the songbird.Journal of neuroendocrinology · 2023Review
- Brain and circulating steroids in an electric fish: Relevance for non-breeding aggression.PloS one · 2023Article
- Immunofluorescent Evidence for Nuclear Localization of Aromatase in Astrocytes in the Rat Central Nervous System.International journal of molecular sciences · 2022Article
- A neural circuit perspective on brain aromatase.Frontiers in neuroendocrinology · 2022Review
- Non-sensory Influences on Auditory Learning and Plasticity.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Review
- A sex-specific feedback projection from aromatase-expressing neurons in the medial amygdala to the accessory olfactory bulb.The Journal of comparative neurology · 2022Article
- Aromatase in the Human Brain.Androgens: clinical research and therapeutics · 2021Review
- Sexually differentiated and neuroanatomically specific co-expression of aromatase neurons and GAD67 in the male and female quail brain.The European journal of neuroscience · 2020Article
- Article
- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding.Frontiers in neuroendocrinology · 2020Review
- Neurochemical organization of the ventral striatum's olfactory tubercle.Journal of neurochemistry · 2020Review
- Estrogen Formation and Inactivation Following TBI: What we Know and Where we Could go.Frontiers in endocrinology · 2020Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Sex steroids have long been recognized for their dramatic impact on brain and behavior, including rapid modulation of membrane excitability. It is a widely held perception that these molecules are largely derived from peripheral sources and lack the spatial and temporal specificity ascribed to classical neuromodulatory systems. Neuromodulatory systems, in contrast, are defined by their regulated neuronal presynaptic secretion and by their functional modulation of perisynaptic events. Here we provide evidence for regulated presynaptic estrogen synthesis and functional postsynaptic actions. These results meet all the criteria for a neuromodulatory system and shift our perception of estrogens from that of peripheral signals exclusively to include that of a signaling system intrinsic to the brain itself. We apply the term synaptocrine to describe this form of neuromodulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.