Evidence map›Paper›PMID 21622287›Full record

ReviewFrontiers in bioscience (Scholar edition)2011

Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.

Dapeng Zhou, Steven B Levery, Fong-Fu Hsu, Peng G Wang, Susann Teneberg, Igor C Almeida, Yunsen Li, Huaxi Xu, Lai-Xi Wang, Chengfeng Xia and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in bioscience (Scholar edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Mass spectrometric analysis of glycosphingolipid antigens.Journal of visualized experiments : JoVE · 2013
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dapeng ZhouDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. dzhou@mdanderson.org
Steven B Levery
Fong-Fu Hsu
Peng G Wang
Susann Teneberg
Igor C Almeida
Yunsen Li
Huaxi Xu
Lai-Xi Wang
Chengfeng Xia
Nuhad K Ibrahim
Katja Michael

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Endogenous glycosphingolipid antigens for NKT cellsR01AI079232 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ZHOU, DAPENG · 2009 to 2013
$1.9M
Alpha-galactosycleramide as a mucosal adjuvant for HIV antigensR21AI078898 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SASTRY, JAGANNADHA K · 2009 to 2010
$424k
NCI NIH HHS CA16672NCI NIH HHS P30 CA016672NIAID NIH HHS AI078898NIAID NIH HHS AI079232NIAID NIH HHS P30 AI036211NIAID NIH HHS P30-AI36211NIAID NIH HHS R01 AI079232NIAID NIH HHS R21 AI078898
6 · The paper itself

Abstract

Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.

Indexed as

Adaptive ImmunityAntigens, SurfaceEpitopesGalectinsGlycoconjugatesGlycomicsHumansLectinsLectins, C-TypeMass SpectrometryNeoplasmsPolysaccharidesReceptors, Antigen, T-CellSialic Acid Binding Immunoglobulin-like LectinsSignal TransductionAntigens, SurfaceEpitopesGalectinsGlycoconjugatesLectinsLectins, C-TypePolysaccharidesReceptors, Antigen, T-CellSialic Acid Binding Immunoglobulin-like Lectins

Identifiers

PMID21622287
PMCPMC3548420

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.