ReviewFrontiers in bioscience (Landmark edition)2011
Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.
Review in Frontiers in bioscience (Landmark edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Transcriptomic landscape of Atlantic salmon (Salmo salar L.) skin.G3 (Bethesda, Md.) · 2023Pooled it
- The role and mechanisms of bone microenvironment regulators in osteoporosis: novel intervention strategies for addressing the challenges of aging.Frontiers in endocrinology · 2026Review
- Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease.Clinical science (London, England : 1979) · 2025Review
- Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.Biomaterials · 2025Article
- Collagen Alpha 1(XI) Amino-Terminal Domain Modulates Type I Collagen Fibril Assembly.Biochemistry · 2025Article
- A high-calcium environment induced ectopic calcification of renal interstitial fibroblasts via TFPI-2-DCHS1-ALP/ENPP1 axis to participate in Randall's plaque formation.Urolithiasis · 2024Article
- Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.bioRxiv : the preprint server for biology · 2024Article
- From bone to nanoparticles: development of a novel generation of bone derived nanoparticles for image guided orthopedic regeneration.Biomaterials science · 2024Article
- Research progress of biomimetic materials in oral medicine.Journal of biological engineering · 2023Review
- Dual-Crosslinking of Gelatin-Based Hydrogels: Promising Compositions for a 3D Printed Organotypic Bone Model.Bioengineering (Basel, Switzerland) · 2023Article
- Combined Application of Dentin Noncollagenous Proteins and Odontogenic Biphasic Calcium Phosphate in Rabbit Maxillary Sinus Lifting.Tissue engineering and regenerative medicine · 2023Article
- Long non-coding RNA CASC2 regulates osteoblasts matrix mineralization.Frontiers in bioengineering and biotechnology · 2023Article
- Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity.Scientific reports · 2022Article
- Article
- Osteogenic transdifferentiation of primary human fibroblasts to osteoblast-like cells with human platelet lysate.Scientific reports · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
- Engineered Cell-Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of Mineralized Tissues.Advanced healthcare materials · 2022Article
- Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics.Biophysical journal · 2022Article
- Nanoscale mineralization of cell-laden methacrylated gelatin hydrogels using calcium carbonate-calcium citrate core-shell microparticles.Journal of materials chemistry. B · 2021Article
- Human kidney stones: a natural record of universal biomineralization.Nature reviews. Urology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The impact of genetics has dramatically affected our understanding of the functions of non-collagenous proteins. Specifically, mutations and knockouts have defined their cellular spectrum of actions. However, the biochemical mechanisms mediated by non-collagenous proteins in biomineralization remain elusive. It is likely that this understanding will require more focused functional testing at the protein, cell, and tissue level. Although initially viewed as rather redundant and static acidic calcium binding proteins, it is now clear that non-collagenous proteins in mineralizing tissues represent diverse entities capable of forming multiple protein-protein interactions which act in positive and negative ways to regulate the process of bone mineralization. Several new examples from the author's laboratory are provided which illustrate this theme including an apparent activating effect of hydroxyapatite crystals on metalloproteinases. This review emphasizes the view that secreted non-collagenous proteins in mineralizing bone actively participate in the mineralization process and ultimately control where and how much mineral crystal is deposited, as well as determining the quality and biomechanical properties of the mineralized matrix produced.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.