ReviewFrontiers in bioscience (Landmark edition)2011
Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways.
Review in Frontiers in bioscience (Landmark edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Nitric oxide in the occurrence and development of ischemic cerebrovascular disease.Medical gas research · 2027Review
- Comparative study of the role of nitric oxide in the regulation of food intake across vertebrates.Journal of veterinary science · 2026Review
- Making Neurobots and Chimerical Ctenophores.bioRxiv : the preprint server for biology · 2024Article
- Nitric oxide sensor NsrR is the key direct regulator of magnetosome formation and nitrogen metabolism in Magnetospirillum.Nucleic acids research · 2024Article
- Neuronal gene expression in two generations of the marine parasitic worm, Cryptocotyle lingua.Communications biology · 2023Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Nitric oxide suppresses cilia activity in ctenophores.bioRxiv : the preprint server for biology · 2023Article
- Article
- Nitric oxide signaling in ctenophores.Frontiers in neuroscience · 2023Article
- Recording cilia activity in ctenophores: effects of nitric oxide and low molecular weight transmitters.Frontiers in neuroscience · 2023Article
- Expression Pattern ofGenes · 2022Article
- Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.Journal of morphology · 2022Article
- The American lobster genome reveals insights on longevity, neural, and immune adaptations.Science advances · 2021Article
- Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Bivalves are NO different: nitric oxide as negative regulator of metamorphosis in the Pacific oyster, Crassostrea gigas.BMC developmental biology · 2020Article
- Puncta of Neuronal Nitric Oxide Synthase (nNOS) Mediate NMDA Receptor Signaling in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems.AIMS neuroscience · 2019Review
- Nitric Oxide Accumulation: The Evolutionary Trigger for Phytopathogenesis.Frontiers in microbiology · 2017Article
- Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.Medical oncology (Northwood, London, England) · 2016Article
- Independent origins of neurons and synapses: insights from ctenophores.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The origin of NO signaling can be traceable back to the origin of life with the large scale of parallel evolution of NO synthases (NOSs). Inducible-like NOSs may be the most basal prototype of all NOSs and that neuronal-like NOS might have evolved several times from this prototype. Other enzymatic and non-enzymatic pathways for NO synthesis have been discovered using reduction of nitrites, an alternative source of NO. Diverse synthetic mechanisms can co-exist within the same cell providing a complex NO-oxygen microenvironment tightly coupled with cellular energetics. The dissection of multiple sources of NO formation is crucial in analysis of complex biological processes such as neuronal integration and learning mechanisms when NO can act as a volume transmitter within memory-forming circuits. In particular, the molecular analysis of learning mechanisms (most notably in insects and gastropod molluscs) opens conceptually different perspectives to understand the logic of recruiting evolutionarily conserved pathways for novel functions. Giant uniquely identified cells from Aplysia and related species precent unuque opportunities for integrative analysis of NO signaling at the single cell level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.