ArticleClinical immunology (Orlando, Fla.)2011
Simian immunodeficiency virus infection in rhesus macaques induces selective tissue specific B cell defects in double positive CD21+CD27+ memory B cells.
Article in Clinical immunology (Orlando, Fla.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies.Comprehensive physiology · 2025Review
- Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection.JCI insight · 2024Article
- Systemic and Intestinal Viral Reservoirs in CD4+ T Cell Subsets in Primary SIV Infection.Viruses · 2021Article
- Immunological Responses to the Relapsing Fever SpirocheteInfection and immunity · 2019Article
- Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.The Journal of general virology · 2019Article
- Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques.PloS one · 2017Article
- Article
- Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.Virology journal · 2016Article
- Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.PLoS pathogens · 2015Article
- Article
- Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques.Immunogenetics · 2015Article
- Article
- Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques (Macaca leonina).Dong wu xue yan jiu = Zoological research · 2014Article
- Lack of interleukin-10-mediated anti-inflammatory signals and upregulated interferon gamma production are linked to increased intestinal epithelial cell apoptosis in pathogenic simian immunodeficiency virus infection.Journal of virology · 2014Article
- Phenotypes and distribution of mucosal memory B-cell populations in the SIV/SHIV rhesus macaque model.Clinical immunology (Orlando, Fla.) · 2014Article
- Effects of alcohol consumption on antigen-specific cellular and humoral immune responses to SIV in rhesus macaques.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.Journal of virology · 2013Article
- Fc receptor-mediated immune responses: new tools but increased complexity in HIV prevention.Current HIV research · 2013Article
- Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.PLoS pathogens · 2013Article
- Key Concepts in the Early Immunology of HIV-1 Infection.Current infectious disease reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
B cell dysfunction represents a central feature in HIV infection and pathogenesis. Our recent studies have shown that peripheral and lymphoid double positive CD21+CD27+ B cells were able to become activated and proliferate at higher rates than other B cell subpopulations. Increased proliferation of tonsillar memory B cells was identified compared to other tissues examined. Here, we demonstrate the decreased proliferation of tonsillar memory (CD21+CD27+) B cells during acute SIV infection also suggests that these cells may play an important role in SIV pathogenesis. Our findings demonstrate that SIV infection may induce selective defective responses in specific tissues, by suppressing memory B cell proliferation in tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.