ArticleFree radical biology & medicine2011
GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone.
Article in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The effect of ambient ozone exposure on three types of diabetes: a meta-analysis.Environmental health : a global access science source · 2023Pooled it
- The micro-743a-3p-GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice.Cellular & molecular biology letters · 2024Article
- Air Pollution as a Risk Indicator for Periodontitis.Biomedicines · 2023Article
- [Current and future effects of climate change on ophthalmology].Die Ophthalmologie · 2022Review
- Ozone Responsive Gene Expression as a Model for Describing Repeat Exposure Response Trajectories and Interindividual Toxicodynamic Variability In Vitro.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Short-Term Effects of Ambient Ozone, PMInternational journal of environmental research and public health · 2020Article
- Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China.Journal of translational medicine · 2019Article
- Recent developments in the role of reactive oxygen species in allergic asthma.Journal of thoracic disease · 2017Review
- Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- SRC-mediated EGF receptor activation regulates ozone-induced interleukin 8 expression in human bronchial epithelial cells.Environmental health perspectives · 2015Article
- Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium.Allergy · 2014Article
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- Genes of innate immunity and the biological response to inhaled ozone.Journal of biochemical and molecular toxicology · 2013Review
- Role of GSTM1 in resistance to lung inflammation.Free radical biology & medicine · 2012Review
- ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.Inflammation · 2012Article
- The effect of environmental oxidative stress on airway inflammation.Current opinion in allergy and clinical immunology · 2012Review
- Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Exposure to the major air pollutant ozone can aggravate asthma and other lung diseases. Our recent study in human volunteers has shown that the glutathione S-transferase Mu 1 (GSTM1)-null genotype is associated with increased airway neutrophilic inflammation induced by inhaled ozone. The aim of this study was to examine the effect of GSTM1 modulation on interleukin 8 (IL-8) production in ozone-exposed human bronchial epithelial cells (BEAS-2B) and the underlying mechanisms. Exposure of BEAS-2B cells to 0.4 ppm ozone for 4 h significantly increased IL-8 release, with a modest reduction in intracellular reduced glutathione (GSH). Ozone exposure induced reactive oxygen species (ROS) production and NF-κB activation. Pharmacological inhibition of NF-κB activation or mutation of the IL-8 promoter at the κB-binding site significantly blocked ozone-induced IL-8 production or IL-8 transcriptional activity, respectively. Knockdown of GSTM1 in BEAS-2B cells enhanced ozone-induced NF-κB activation and IL-8 production. Consistently, an ozone-induced overt increase in IL-8 production was detected in GSTM1-null primary human bronchial epithelial cells. In addition, supplementation with reduced GSH inhibited ozone-induced ROS production, NF-κB activation, and IL-8 production. Taken together, GSTM1 deficiency enhances ozone-induced IL-8 production, which is mediated by generated ROS and subsequent NF-κB activation in human bronchial epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.