ArticleThe Journal of allergy and clinical immunology2011
Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.Nature communications · 2020Pooled it
- An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.The Journal of allergy and clinical immunology · 2019Pooled it
- Replication and fine mapping of asthma-associated loci in individuals of African ancestry.Human genetics · 2013Pooled it
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- Integrative approach identifies corticosteroid response variant in diverse populations with asthma.The Journal of allergy and clinical immunology · 2019Article
- Article
- Genome-wide methylation data mirror ancestry information.Epigenetics & chromatin · 2017Article
- Asthma in Puerto Ricans: Lessons from a high-risk population.The Journal of allergy and clinical immunology · 2016Article
- Genetic ancestry influences asthma susceptibility and lung function among Latinos.The Journal of allergy and clinical immunology · 2015Article
- Exploration of the Genetic Epidemiology of Asthma: A Review, with a Focus on Prevalence in Children and Adolescents in the Caribbean.The West Indian medical journal · 2014Article
- Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.BMC medical genomics · 2014Article
- Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.The Journal of allergy and clinical immunology · 2014Article
- Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.Science (New York, N.Y.) · 2014Article
- Asthma in Hispanics. An 8-year update.American journal of respiratory and critical care medicine · 2014Review
- Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: the Genes-environments and Admixture in Latino Asthmatics (GALA II) study.The Journal of allergy and clinical immunology · 2013Article
- Validation of PPP1R12B as a candidate gene for childhood asthma in Russians.Journal of genetics · 2013Article
- A twin study of early-childhood asthma in Puerto Ricans.PloS one · 2013Article
- Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects.PloS one · 2013Article
- Case-control admixture mapping in Latino populations enriches for known asthma-associated genes.The Journal of allergy and clinical immunology · 2012Article
- Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population.Pediatric allergy, immunology, and pulmonology · 2011Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundAlthough Mexicans and Puerto Ricans are jointly classified as "Hispanic/Latino," there are significant differences in asthma prevalence, severity, and mortality between the 2 groups. We sought to examine the possibility that population-specific genetic risks contribute to this disparity.
objectivesMore than 100 candidate genes have been associated with asthma and replicated in an independent population, and 7 genome-wide association studies in asthma have been performed. We compared the pattern of replication of these associations in Puerto Ricans and Mexicans.
methodsWe genotyped Mexican and Puerto Rican trios using an Affymetrix 6.0 GeneChip and used a family-based analysis to test for genetic associations in 124 genes previously associated with asthma.
resultsWe identified 32 single nucleotide polymorphisms (SNPs) in 17 genes associated with asthma in at least 1 of the 2 populations. Twenty-two of these SNPs in 11 genes were significantly associated with asthma in the combined population and showed no significant heterogeneity of association, whereas 5 SNPs were associated in only 1 population and showed statistically significant heterogeneity. In a gene-based approach 2 additional genes were associated with asthma in the combined population, and 3 additional genes displayed ethnic-specific associations with heterogeneity.
conclusionsOur results show that only a minority of genetic association studies replicate in our population of Mexican and Puerto Rican asthmatic subjects. Among SNPs that were successfully replicated, most showed no significant heterogeneity across populations. However, we identified several population-specific genetic associations.
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