ReviewProgress in neurobiology2011
Mechanisms of specificity in neuronal activity-regulated gene transcription.
Review in Progress in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene expression in stress urinary incontinence: a systematic review.International urogynecology journal · 2020Pooled it
- Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling.bioRxiv : the preprint server for biology · 2026Article
- A Squeak Is Not Enough: Female Presence and Vocal Playback Have Contrasting Effects on c-Fos Expression by Dorsal Raphé Neurons in Lab Mice.Brain sciences · 2026Article
- N-type CaNPJ Parkinson's disease · 2025Article
- mRNA Isoforms and Variants in Health and Disease.International journal of molecular sciences · 2025Review
- Synergistic roles of NFATc1 and c-Jun in immunomodulation.Biochemistry and biophysics reports · 2025Review
- An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles.Hormones and behavior · 2025Article
- Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward.Science advances · 2025Article
- Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.Neurophotonics · 2025Review
- Transcriptomic Analysis Reveals the Heterogeneous Role of Conducting Films Upon Electrical Stimulation.Advanced healthcare materials · 2024Article
- Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus.Biomedicines · 2024Article
- Spatially Resolved Transcriptomic Signatures of Hippocampal Subregions andbioRxiv : the preprint server for biology · 2024Article
- Spatially resolved transcriptomic signatures of hippocampal subregions andFrontiers in molecular neuroscience · 2024Article
- Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons.Frontiers in neuroscience · 2024Article
- All IEGs Are Not Created Equal-Molecular Sorting Within the Memory Engram.Advances in neurobiology · 2024Review
- Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders.Molecular neurobiology · 2023Review
- DHHC2 regulates fear memory formation, LTP, and AKAP150 signaling in the hippocampus.iScience · 2023Article
- Cellular profiling of a recently-evolved social behavior in cichlid fishes.Nature communications · 2023Article
- Flow Cytometry of Synaptoneurosomes (FCS) Reveals Increased Ribosomal S6 and Calcineurin Proteins in Activated Medial Prefrontal Cortex to Nucleus Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging.Micromachines · 2023Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary advantage. Neurons convert environmental stimuli into long-lasting changes in their physiology in part through the synaptic activity-regulated transcription of new gene products. Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways that mediate activity-regulated changes in gene transcription. These findings show that a broad range of signaling pathways and transcriptional regulators can be engaged by neuronal activity to sculpt complex programs of stimulus-regulated gene transcription. However, the shear scope of the transcriptional pathways engaged by neuronal activity raises the question of how specificity in the nature of the transcriptional response is achieved in order to encode physiologically relevant responses to divergent stimuli. Here we summarize the general paradigms by which neuronal activity regulates transcription while focusing on the molecular mechanisms that confer differential stimulus-, cell-type-, and developmental-specificity upon activity-regulated programs of neuronal gene transcription. In addition, we preview some of the new technologies that will advance our future understanding of the mechanisms and consequences of activity-regulated gene transcription in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.