ArticleCurrent biology : CB2011
Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Uncovering core regulators of multi-abiotic stress adaptation in Arabidopsis thaliana through integrative meta-analysis and machine learning with RT-qPCR validation.Scientific reports · 2026Pooled it
- Endochitinase Overexpression in Transgenic Tomato Plants Improves Resistance to Phytopathogens.Biotechnology journal · 2026Article
- Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance.Plant physiology · 2026Article
- The plastid cysteine synthase complex regulates ABA biosynthesis and stomatal closure in Arabidopsis.Nature communications · 2025Article
- Identification of a novel stomatal opening chemical, PP242, that inhibits early abscisic acid signal transduction in guard cells.Plant & cell physiology · 2025Article
- Discovering leaf and stripe rust resistance in soft red winter wheat through genome-wide association studies.The plant genome · 2025Article
- Decursin, Identified via High-Throughput Chemical Screening, Enhances Plant Disease Resistance via Two Independent Mechanisms.Molecular plant pathology · 2025Article
- A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth.iScience · 2025Article
- Review
- Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain.Nature communications · 2024Article
- Small chemical molecules regulating the phytohormone signalling alter the plant's physiological processes to improve stress adaptation, growth and productivity.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Identification of the Novel Small Compound Stress Response Regulators 1 and 2 That Affect Plant Abiotic Stress Signaling.Biomolecules · 2024Article
- The Discovery of Highly Efficient and Promising ABA Receptor Antagonists for Agricultural Applications Based on APAn Modification.Molecules (Basel, Switzerland) · 2024Article
- Highlights in gibberellin research: A tale of the dwarf and the slender.Plant physiology · 2024Review
- Small holes, big impact: Stomata in plant-pathogen-climate epic trifecta.Molecular plant · 2024Review
- SCAB1 coordinates sequential CaScience China. Life sciences · 2024Article
- Arabidopsis PLANT U-BOX44 down-regulates osmotic stress signaling by mediating Ca2+-DEPENDENT PROTEIN KINASE4 degradation.The Plant cell · 2023Article
- Novel Compounds Derived from DFPM Induce Root Growth Arrest through the SpecificLife (Basel, Switzerland) · 2023Article
- Identification of stomatal-regulating molecules from de novo arylamine collection through aromatic C-H amination.Scientific reports · 2022Article
- ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers.Science advances · 2021Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Coordinated regulation of protection mechanisms against environmental abiotic stress and pathogen attack is essential for plant adaptation and survival. Initial abiotic stress can interfere with disease-resistance signaling [1-6]. Conversely, initial plant immune signaling may interrupt subsequent abscisic acid (ABA) signal transduction [7, 8]. However, the processes involved in this crosstalk between these signaling networks have not been determined. By screening a 9600-compound chemical library, we identified a small molecule [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione (DFPM) that rapidly downregulates ABA-dependent gene expression and also inhibits ABA-induced stomatal closure. Transcriptome analyses show that DFPM also stimulates expression of plant defense-related genes. Major early regulators of pathogen-resistance responses, including EDS1, PAD4, RAR1, and SGT1b, are required for DFPM-and notably also for Pseudomonas-interference with ABA signal transduction, whereas salicylic acid, EDS16, and NPR1 are not necessary. Although DFPM does not interfere with early ABA perception by PYR/RCAR receptors or ABA activation of SnRK2 kinases, it disrupts cytosolic Ca(2+) signaling and downstream anion channel activation in a PAD4-dependent manner. Our findings provide evidence that activation of EDS1/PAD4-dependent plant immune responses rapidly disrupts ABA signal transduction and that this occurs at the level of Ca(2+) signaling, illuminating how the initial biotic stress pathway interferes with ABA signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.