ArticleMatrix biology : journal of the International Society for Matrix Biology2011
Molecular simulations predict novel collagen conformations during cross-link loading.
Article in Matrix biology : journal of the International Society for Matrix Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
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- Multiscale modelling of the extracellular matrix.Matrix biology plus · 2022Article
- Molecular and structural basis of actin filament severing by ADF/cofilin.Computational and structural biotechnology journal · 2022Article
- Mechanism of collagen folding propagation studied by Molecular Dynamics simulations.PLoS computational biology · 2021Article
- Collagen peptide simulated bending after applied axial deformation.Journal of the mechanical behavior of biomedical materials · 2020Article
- Probing mechanical properties and failure mechanisms of fibrils of self-assembling peptides.Nanoscale advances · 2020Article
- Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Non-enzymatic cross-linking of collagen type II fibrils is tuned via osmolality switch.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Effect on the mechanical properties of type I collagen of intra-molecular lysine-arginine derived advanced glycation end-product cross-linking.Journal of biomechanics · 2018Article
- Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils.Journal of the mechanical behavior of biomedical materials · 2015Article
- Glycation cross-linking induced mechanical-enzymatic cleavage of microscale tendon fibers.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
- A new paradigm for mechanobiological mechanisms in tumor metastasis.Seminars in cancer biology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Collagen cross-linking mechanically strengthens tissues during development and aging, but there is limited data describing how force transmitted across cross-links affects molecular conformation. We used Steered Molecular Dynamics (SMD) to model perpendicular force through a side chain. Results predicted that collagen peptides have negligible bending resistance and that mechanical force causes helix disruption below covalent bond failure strength, suggesting alternative molecular conformations precede cross-link rupture and macroscopic damage during mechanical loading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.