Evidence map›Paper›PMID 21620466›Full record

ReviewLancet (London, England)2011

Pancreatic cancer.

Audrey Vincent, Joseph Herman, Rich Schulick, Ralph H Hruban, Michael Goggins

8 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Lancet (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 1,533 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,533citing papers in PubMed, 3 pooled it
45.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01734967 nacompletednot on this mapstarted 2012, after this paper: background citation

Needle-based Confocal Endomicroscopy Examination of Pancreatic Masses

TypeinterventionalSponsorHerlev HospitalRan2012 to 2016Enrolled28ConditionsPancreatic Neoplasms, CHRONIC PANCREATITISArmsneedle based CLE, EUS-FNA
NCT03166436 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Radiofrequency Ablation Plus Stenting Versus Stenting Alone for Treatment of Malignant Biliary Obstruction

TypeinterventionalSponsorInstitute for Clinical and Experimental MedicineRan2017 to 2020Enrolled140ConditionsCholangiocarcinoma, Pancreas CancerArmsRadiofrequency ablation, Biliary stenting
NCT03632850 completednot on this mapstarted 2019, after this paper: background citation

Shared Decision-making: Investigating the Potential of an Interactive, Web-Based, Information Tool for People With Advanced Pancreatic Cancer

TypeobservationalSponsorBournemouth UniversityRan2019 to 2021Enrolled34ConditionsAdvanced Pancreatic CancerArmsweb-based interactive tool
NCT04276857 narecruitingnot on this mapstarted 2025, after this paper: background citation

Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer: The SMART Study

TypeinterventionalSponsorUniversity of SaskatchewanRan2025 to 2026Enrolled27ConditionsLocally Advanced Pancreatic Cancer, Irreversible ElectroporationArmsIrreversible electroporation (NanoKnife® )
NCT04986215 unknown statusnot on this mapstarted 2020, after this paper: background citation

Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy

TypeobservationalSponsorChanghai HospitalRan2020 to 2023Enrolled300ConditionsPancreatic Space Occupying
NCT06388967 recruitingnot on this mapstarted 2023, after this paper: background citation

Early Detection of Pancreatic Cancer: Prospective Study

TypeobservationalSponsorCity of Hope Medical CenterRan2023 to 2030Enrolled2,000ConditionsPancreatic Cancer, Pancreatic Carcinoma, Pancreatic Adenocarcinoma, Pancreatic Ductal AdenocarcinomaArmsPANcreatic cancer Exosome Early detectiON (PANXEON)
NCT07136324 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Safety and Efficacy of Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA) in the Treatment of Pancreatic Lesions: A Prospective Registry

Typeobservational_patient_registrySponsorThe University of Texas Health Science Center, HoustonRan2018 to 2028Enrolled100ConditionsPancreatic CystArmsEUS-guided RFA treatment
NCT07173387 phase2active not recruitingnot on this mapstarted 2025, after this paper: background citation

Stereotactic Body Radiotherapy and NALIRIFOX for Locally Advanced Pancreatic Cancer: A Prospective Clinical Trial

TypeinterventionalSponsorShandong Cancer Hospital and InstituteRan2025 to 2028Enrolled42ConditionsPancreatic CancerArmsNALIRIFOX (liposomal irinotecan-based chemotherapy)., Stereotactic Body Radiation Therapy (SBRT).
3 · Its place in the literature

Who cites it

1,533 citing papers in PubMed, 3 syntheses or guidelines pooled it, 2,569 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  11. Exploring facilitators and barriers to the implementation of prehabilitation for individuals with pancreatic cancer: a survey of healthcare professionals.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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  15. Metastasis-SpecificJournal of clinical medicine · 2026
    Article
  16. Article
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  18. Review
  19. Review
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1,473 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Audrey VincentDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21231, USA.
Joseph Herman
Rich Schulick
Ralph H Hruban
Michael Goggins
Cancer Research Center · USJohns Hopkins University · US

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6M
Predicting pancreatic cancer responses for a Parp inhibitor-based clinical trialRC2CA148346 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2009 to 2010
$1.9M
Markers of Early Pancreatic CancerR01CA120432 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2006 to 2010
$1.4M
NCI NIH HHS CA120432NCI NIH HHS CA62924NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA120432NCI NIH HHS RC2 CA148346NCI NIH HHS RC2CA148346
6 · The paper itself

Abstract

Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80-85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsHumansRisk Factors

Identifiers

PMID21620466
PMCPMC3062508
OpenAlexW4211208840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.