ArticleProceedings of the National Academy of Sciences of the United States of America1990
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 187 citations in OpenAlex.
- In Vitro Anti-cancer Effect of Crataegus oxyacantha Berry Extract on Hormone Receptor Positive and Triple Negative Breast Cancers via Regulation of Canonical Wnt Signaling Pathway.Applied biochemistry and biotechnology · 2023Article
- Fibroblast growth factor 3 promotes spontaneous mammary tumorigenesis in Tientsin albino 2 miceFrontiers in oncology · 2023Article
- Circular RNA circRNA_0067934 promotes glioma development by modulating the microRNA miR-7/ Wnt/β-catenin axis.Bioengineered · 2022Article
- Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases.Oxidative medicine and cellular longevity · 2022Review
- Disruption of entireeLife · 2021Article
- Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach InvolvingFrontiers in neurology · 2020Review
- The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda.Viruses · 2019Review
- Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.Genes & diseases · 2018Review
- Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1.Journal of cell science · 2018Article
- Wnt/beta-catenin pathway: modulating anticancer immune response.Journal of hematology & oncology · 2017Review
- Lessons Learned from Mouse Mammary Tumor Virus in Animal Models.ILAR journal · 2016Article
- Regulation of ephrin-A expression in compressed retinocollicular maps.Developmental neurobiology · 2013Article
- Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.Cell reports · 2013Article
- Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Three decades of Wnts: a personal perspective on how a scientific field developed.The EMBO journal · 2012Review
- Systematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cells.Cell & bioscience · 2011Article
- Shared signaling pathways in normal and breast cancer stem cells.Journal of carcinogenesis · 2011Article
- Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture.Cell stem cell · 2010Article
- Primary cilia regulate branching morphogenesis during mammary gland development.Current biology : CB · 2010Article
- Zebrafish wnt3 is expressed in developing neural tissue.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a common insertion site, Wnt-3, for proviruses of the mouse mammary tumor virus (MMTV). Of mammary tumors induced by the GR variant of MMTV, 5% contains a provirus at Wnt-3, which is located on mouse chromosome 11. The gene is transcribed into a 3.8-kilobase (kb) mRNA in tumors with nearby proviral insertions but not in tumors with proviruses at other loci or in most adult tissues. Normal expression of Wnt-3 is detected in mouse embryos (with a peak around day 12 of gestation) and at low levels in adult brain. The transcriptional unit of the Wnt-3 gene spans approximately 55 kb, with a first intron of 36 kb. The deduced amino acid sequence of the Wnt-3 protein is 47% identical to the int-1/Wnt-1 gene product.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.