ArticlePflugers Archiv : European journal of physiology1990
Effects of purinergic stimulation on the Ca current in single frog cardiac cells.
Article in Pflugers Archiv : European journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Detection of caveolin-3/caveolin-1/P2X7R complexes in mice atrial cardiomyocytes in vivo and in vitro.Histochemistry and cell biology · 2012Article
- P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells.The Journal of physiology · 2003Article
- Extracellular ATP-induced calcium channel inhibition mediated by P1/P2Y purinoceptors in hamster submandibular ganglion neurons.British journal of pharmacology · 2003Article
- Modulation by extracellular ATP of L-type calcium channels in guinea-pig single sinoatrial nodal cell.British journal of pharmacology · 1996Article
- Lusitropic effects of alpha- and beta-adrenergic stimulation in amphibian heart.Molecular and cellular biochemistry · 1994Article
- M1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes.The Journal of physiology · 1993Article
- Modulation of L-type Ca channel activity by P2-purinergic agonist in cardiac cells.Pflugers Archiv : European journal of physiology · 1993Article
- Functional expression of P2Y purinoceptor in Xenopus oocyte injected with brain mRNA.Pflugers Archiv : European journal of physiology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca current (ICa) was measured by whole-cell voltage clamp in single cells isolated from frog ventricle, in which the Na current was inhibited by tetrodotoxin (0.3 microM) and K currents were blocked by substituting K with 120 mM intracellular and 20 mM extracellular Cs. The influence of stimulation by ATP (0.1-100 microM) was assessed in the presence of propranolol (1 microM) or pindolol (0.1 microM), prazozin (0.1 microM) and atropine (10 microM). ATP, in the micromolar range, had two types of effect. Like other P1-purinoagonists, it antagonized the increase in ICa elicited by beta-adrenostimulation. When added alone, 1 microM ATP could increase ICa up to twofold. An increase in ICa was also observed even after it had been maximally enhanced by intracellularly applied cAMP (50 microM). Voltage dependence and kinetics of ICa were not affected. These effects were considered to be related to P2-purinoceptor activation. At higher ATP concentrations the increase in ICa was less; at 100 microM, ATP reduced ICa. The ATP-induced increase in ICa was prevented by internal perfusion of the cells with GDP [beta-S] or neomycin, respectively, to block signal transduction to phospholipase C or its phosphodiesterase activity on the polyphosphoinositides. We conclude that P2-purinoceptor stimulation increases the Ca current in frog ventricular cells by a pathway that might involve phosphoinositide turnover.
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