ArticleBMC health services research2011
Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from 2003 to 2007 of ICD-10-coded routine data.
Article in BMC health services research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.European journal of clinical pharmacology · 2022Pooled it
- Global burden ofJournal of global health · 2019Pooled it
- ICD-10 codes used to identify adverse drug events in administrative data: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- Trial
- Proposed ICD-10 framework for identifying emergency department visits that may be impacted by community pharmacy care clinics.International journal of clinical pharmacy · 2026Article
- [Concepts to improve medication safety in older patients].Innere Medizin (Heidelberg, Germany) · 2026Review
- Implied ADR-Admissions: A Cohort Study Introducing a Novel Administrative Data Approach for Identifying Drug-Related Hospitalisations.Drug safety · 2026Article
- [Recording medication errors in Germany-a workshop report].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Article
- Outcomes and drug-related admissions of cardiovascular patients in the emergency department at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.International journal of emergency medicine · 2025Article
- Application of Claims-based Frailty Index to a Structured Electronic Health Record Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Health economic evaluation of a medication safety intervention in elderly care: identifying causal effects in a multi-center quasi-experimental study design.BMC health services research · 2025Article
- Adverse Drug Events in Ambulatory Care: A Cross-Sectional Study.Drug safety · 2025Article
- Development and Evaluation of Interprofessional High-Fidelity Simulation Course on Medication Therapy Consultation for German Pharmacy and Medical Students-A Randomized Controlled Study.Pharmacy (Basel, Switzerland) · 2024Article
- Shortcomings of Administrative Data to Derive Preventive Strategies for Inhospital Drug-Induced Acute Kidney Failure-Insights from Patient Record Analysis.Journal of clinical medicine · 2022Article
- The detection and prevention of adverse drug events in nursing home and home care patients: Study protocol of a quasi-experimental study.Nursing open · 2022Article
- Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data.Revista de saude publica · 2022Article
- Exploring the prevalence and characteristics of adverse drug events among older adults in South Korea using a national health insurance database.Frontiers in pharmacology · 2022Article
- Drug-Related Hospital Admissions and Associated Factors among Adults Admitted to Felege Hiwot Comprehensive and Specialized Hospital, North West Ethiopia.Journal of environmental and public health · 2022Article
- Prevalence and predictors of medication-related emergency department visit in older adults: A multicenter study linking national claim database and hospital medical records.Frontiers in pharmacology · 2022Article
- Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service.Frontiers in pharmacology · 2021Article
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2 authors.
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Abstract
backgroundAdverse reactions and medication errors are complications of drug use. Spontaneous reporting systems and pharmacoepidemiological studies incompletely detect the occurrence of these events in daily hospital care. In this study, the frequency and type of drug-related admissions and hospital-acquired adverse drug events (ADE) in Germany were assessed using routinely collected hospital data.
methodsThe study was based on aggregated hospital routine data covering the period 2003 to 2007 and annually recorded as part of the further development of the German Diagnosis-Related Groups. The 505 ICD-10-codes indicating an ADE were categorized in seven groups according to their certainty. Primary diagnoses were considered as a proxy for drug-related admissions, and secondary diagnoses as a proxy for hospital-acquired ADE.
resultsAmong all hospital admissions, 5% were found to be at least possibly drug-induced and 0.7% very likely drug-induced. There was a significant increase in the overall rate of drug-related admissions over time (p < 0.038). Enterocolitis due to Clostridium difficile infection was the most frequent cause of a drug-related admission. About 4.5% of in-patients had experienced a hospital-acquired ADE. In addition, over the course of the study period, the overall frequency of hospital-acquired ADEs significantly increased (p < 0.001).
conclusionsIn Germany, more than 5% of hospital episodes are either caused or complicated by an ADE. Between 2003 and 2007, there was a statistically significant increase in the overall rate and in some of the subcategories defined by the list of ICD-10-codes suspected to be indicative of an ADE. Before the use of routine data in pharmacovigilance and patient safety can be fully exploited, a further tailoring of both the ICD and the available variable set is needed.
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