ArticleLipids in health and disease2011
Lipid lowering by hydroalcoholic extracts of Amaranthus caudatus L. induces regression of rabbits atherosclerotic lesions.
Article in Lipids in health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies.Journal of translational medicine · 2016Pooled it
- Comparison of the Effect of Amaranth Oil vs. Rapeseed Oil on Selected Atherosclerosis Markers in Overweight and Obese Subjects: A Randomized Double-Blind Cross-Over Trial.International journal of environmental research and public health · 2021Trial
- Trial
- Antioxidant Activity of Anthocyanins and Anthocyanidins: A Critical Review.International journal of molecular sciences · 2024Review
- Review
- Article
- Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2020Review
- Productive and Qualitative Traits of Amaranthus Cruentus L.: An Unconventional Healthy Ingredient in Animal Feed.Animals : an open access journal from MDPI · 2020Article
- Assessment of the Antioxidant/Hypolipidemic Relationship ofMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe antihypercholesterolemic and antiatherogenic effect of hydroalcoholic extracts of Amaranthus caudatus L (A. caudatus). on regression of atherosclerosis in experimental rabbits maintained on a high cholesterol diet.
methodsTwenty five rabbits were randomly divided into five groups of five each and treated 75 days as follows: Group I: normal diet(ND), Group II: Hypercholesterolemic diet (HCD) for 45 days; Group III: Hypercholesterolemic diet (HCD) for 75 days, Group IV and V: HCD for 45 days and then normal diet and normal diet + A. caudatus(150 mg·kg day) respectively for an additional 30 days(regression period). Blood samples were collected before (0 time) and after 45 days and 75 days of experimental diets for measurement of biochemical factors. The aortas were removed at the end of the study for assessment of atherosclerotic plaques.
resultsIn regression period dietary use of A. caudatus in group V significantly decreased total cholesterol, LDL-cholesterol, malondialdehyde, C-reactive protein while apolipoproteinA and HDL-cholesterol was significantly increased compared to group IV. The atherosclerotic area was significantly decreased in group V. Whereas, the animals that in regression period received only normal diet showed no regression but rather progression of atherosclerosis.
conclusionThese results thus suggest that hydroalcoholic extracts of A. caudatus can reduce risk factors and cause regression of fatty lesions in aorta.
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