ArticleDepression and anxiety2011
Generalized anxiety disorder and anorexia nervosa: evidence of shared genetic variation.
Article in Depression and anxiety, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- Investigation of polygenic risk scores and subphenotypes in social anxiety disorder.Translational psychiatry · 2026Article
- Cross-Sectional Associations Between Depressive and Anxiety Symptoms and Disordered Eating Behaviors by Sex in University Students.Journal of clinical medicine · 2025Article
- Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies.The Psychiatric clinics of North America · 2025Review
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- Common Genetic and Environmental Contributions to Anxiety Sensitivity, Anxiety, and Cognitive Symptoms of Eating Disorders in Adolescence.Research on child and adolescent psychopathology · 2025Article
- Article
- In pursuit of biomarkers for predicting susceptibility to activity-based anorexia in adolescent female rats.The International journal of eating disorders · 2022Article
- Genetics and neurobiology of eating disorders.Nature neuroscience · 2022Review
- The Role of Problematic Smartphone Uses and Psychological Distress in the Relationship Between Sleep Quality and Disordered Eating Behaviors Among Chinese College Students.Frontiers in psychiatry · 2021Article
- Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach.BMC psychiatry · 2020Article
- Anxiety disorders predict fasting to control weight: A longitudinal large cohort study of adolescents.European eating disorders review : the journal of the Eating Disorders Association · 2020Article
- Genetic and environmental relationships between eating behavior and symptoms of anxiety and depression.Eating and weight disorders : EWD · 2019Article
- Genetics of generalized anxiety disorder and related traits.Dialogues in clinical neuroscience · 2017Review
- Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa.Molecular psychiatry · 2016Article
- Cerebral perfusion differences in women currently with and recovered from anorexia nervosa.Psychiatry research · 2015Article
- Common psychiatric disorders and caffeine use, tolerance, and withdrawal: an examination of shared genetic and environmental effects.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
- Understanding comorbidity: from epidemiological designs and model-fitting approaches to systems biology as a new tool.European child & adolescent psychiatry · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundPrevious studies have indicated a high prevalence of generalized anxiety disorder (GAD) in women with anorexia nervosa (AN). However, the shared genetic and environmental components of these disorders have not been explored. This study seeks to elucidate the shared genetic and environmental components between GAD and AN.
methodUsing 2,083 women from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, structural equation modeling was used to obtain maximum likelihood estimates of the environmental genetic, shared and unique environmental components in 496 women with GAD, 47 women with AN, 43 women with GAD + AN, and 1,497 women without GAD or AN.
resultsResults show that the heritability of GAD was 0.32 and AN was 0.31, and the genetic correlation between the two disorders was 0.20, indicating a modest genetic contribution to their comorbidity. Unique environment estimate was 0.68 for GAD and 0.69 for AN, with a unique environmental correlation of 0.18. All common environmental parameters were estimated at zero.
conclusionsThe modest shared genetic and unique environmental liability to both disorders may help explain the high prevalence of GAD in women with AN. This knowledge could help in the treatment and prevention of comorbid disorders.
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