Evidence map›Paper›PMID 21618575›Full record

SynthesisHepatology (Baltimore, Md.)2011

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis.

Ruben Hernaez, Mariana Lazo, Susanne Bonekamp, Ihab Kamel, Frederick L Brancati, Eliseo Guallar, Jeanne M Clark

5 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hepatology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 728 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
728citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05802199 unknown statusnot on this mapstarted 2023, after this paper: background citation

Quantitative Detection Efficiency of Ultrasound Derived Fat Fraction (UDFF) as a Non-invasive Alternative for Nonalcoholic Fatty Liver Disease (CHESS2303): a Multicenter Prospective Study

Typeobservational_patient_registrySponsorXinhua Hospital, Shanghai Jiao Tong University School of MedicineRan2023 to 2023Enrolled300ConditionsNon-alcoholic Fatty Liver DiseaseArmsHepatic fat fraction and hepatic fibrosis
NCT06334666 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With Metabolic-associated Steatotic Liver Disease: a Randomized-controlled Trial

TypeinterventionalSponsorMahidol UniversityRan2024 to 2026Enrolled86ConditionsDaily Step Count, MASLD, BMI, Metabolic SyndromeArmsEncourage using pedometer
NCT06826807 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Hepatic Elastography-Enhanced Lifestyle Modification in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial

TypeinterventionalSponsorMahidol UniversityRan2025 to 2027Enrolled92ConditionsTransient Elastography, MASLD, BMI, Metabolic SyndromeArmsRegular monitoring with transient elastography
NCT07598916 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Sarcopenia Among Patients With Metabolic Dysfunction-associated Steatotic Liver Disease

TypeobservationalSponsorAssiut UniversityRan2026 to 2027Enrolled120ConditionsSarcopenia Among Patients With Metabolic Dysfunction-associated Steatotic Liver Disease
NCT07750535 recruitingnot on this mapstarted 2024, after this paper: background citation

Prevalence and Risk Factors of Liver Steatosis and Fibrosis in Non-Celiac Wheat Sensitivity Patients: a Prospective Study

TypeobservationalSponsorUniversity of PalermoRan2024 to 2030Enrolled250ConditionsMetabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity, Irritable Bowel Syndrome, Functional DyspepsiaArmsPrevalence and severity of liver steatosis and fibrosis,
3 · Its place in the literature

Who cites it

728 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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668 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruben Hernaez *Department of Medicine The Johns Hopkins School of Medicine, Baltimore, MD.
Mariana Lazo *Department of Medicine The Johns Hopkins School of Medicine, Baltimore, MD.
Susanne BonekampDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD.
Ihab KamelDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD.
Frederick L BrancatiDepartment of Medicine The Johns Hopkins School of Medicine, Baltimore, MD.
Eliseo GuallarDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Jeanne M ClarkDepartment of Medicine The Johns Hopkins School of Medicine, Baltimore, MD.

Funding

Diabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1M
Patient Oriented Research in Type 2 DiabetesK24DK062222 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L · 2002 to 2011
$1.7M
Epidemiology of Ultrasound-Defined NAFLD in the General U.S. PopulationR01DK083393 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 2009 to 2010
$812k
NIDDK NIH HHS 1R01DK083393-01A1NIDDK NIH HHS K24-DK62222NIDDK NIH HHS P60 DK079637NIDDK NIH HHS R01 DK083393
6 · The paper itself

Abstract

unlabelledUltrasonography is a widely accessible imaging technique for the detection of fatty liver, but the reported accuracy and reliability have been inconsistent across studies. We aimed to perform a systematic review and meta-analysis of the diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver. We used MEDLINE and Embase from October 1967 to March 2010. Studies that provided cross-tabulations of ultrasonography versus histology or standard imaging techniques, or that provided reliability data for ultrasonography, were included. Study variables were independently abstracted by three reviewers and double checked by one reviewer. Forty-nine (4720 participants) studies were included for the meta-analysis of diagnostic accuracy. The overall sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of ultrasound for the detection of moderate-severe fatty liver, compared to histology (gold standard), were 84.8% (95% confidence interval: 79.5-88.9), 93.6% (87.2-97.0), 13.3 (6.4-27.6), and 0.16 (0.12-0.22), respectively. The area under the summary receiving operating characteristics curve was 0.93 (0.91-0.95). Reliability of ultrasound for the detection of fatty liver showed kappa statistics ranging from 0.54 to 0.92 for intrarater reliability and from 0.44 to 1.00 for interrater reliability. Sensitivity and specificity of ultrasound was similar to that of other imaging techniques (i.e., computed tomography or magnetic resonance imaging). Statistical heterogeneity was present even after stratification for multiple clinically relevant characteristics.

conclusionUltrasonography allows for reliable and accurate detection of moderate-severe fatty liver, compared to histology. Because of its low cost, safety, and accessibility, ultrasound is likely the imaging technique of choice for screening for fatty liver in clinical and population settings.

Indexed as

Fatty LiverHumansReproducibility of ResultsSensitivity and SpecificityUltrasonography

Identifiers

PMID21618575
PMCPMC4197002

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.