ArticleJournal of cellular physiology2011
Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence.
Article in Journal of cellular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Stretch-induced endogenous electric fields drive directed collective cell migration in vivo.Nature materials · 2025Article
- Voltage sensors.Molecular pharmacology · 2025Review
- The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.Nature communications · 2024Article
- Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase.The Journal of general physiology · 2024Article
- Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes.Communications biology · 2022Article
- Phosphoinositides modulate the voltage dependence of two-pore channel 3.The Journal of general physiology · 2019Article
- The voltage sensing phosphatase (VSP) localizes to the apical membrane of kidney tubule epithelial cells.PloS one · 2019Article
- A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.Cellular and molecular life sciences : CMLS · 2018Article
- Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity.The Journal of general physiology · 2018Article
- Domain-to-domain coupling in voltage-sensing phosphatase.Biophysics and physicobiology · 2017Review
- Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase.Biophysical journal · 2015Article
- Discovery and functional characterization of a neomorphic PTEN mutation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Voltage-sensing phosphatase modulation by a C2 domain.Frontiers in pharmacology · 2015Article
- A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases.Frontiers in pharmacology · 2015Article
- Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research.Frontiers in pharmacology · 2015Review
- Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum.Communicative & integrative biology · 2014Article
- Functional diversity of voltage-sensing phosphatases in two urodele amphibians.Physiological reports · 2014Article
- Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1.PloS one · 2014Article
- Sensing charges of the Ciona intestinalis voltage-sensing phosphatase.The Journal of general physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Voltage-sensitive phosphatases (VSPs) are unique proteins in which membrane potential controls enzyme activity. They are comprised of the voltage sensor domain of an ion channel coupled to a lipid phosphatase specific for phosphoinositides, and for ascidian and zebrafish VSPs, the phosphatase activity has been found to be activated by membrane depolarization. The physiological functions of these proteins are unknown, but their expression in testis and embryos suggests a role in fertilization or development. Here we investigate the expression pattern and voltage dependence of VSPs in two frog species, Xenopus laevis and Xenopus tropicalis, that are well suited for experimental studies of these possible functions. X. laevis has two VSP genes (Xl-VSP1 and Xl-VSP2), whereas X. tropicalis has only one gene (Xt-VSP). The highest expression of these genes was observed in testis, ovary, liver, and kidney. Our results show that while Xl-VSP2 activates only at positive membrane potentials outside of the physiological range, Xl-VSP1 and Xt-VSP phosphatase activity is regulated in the voltage range that regulates sperm-egg fusion at fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.