ArticleJournal of surgical oncology2011
Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?
Article in Journal of surgical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Epidemiology, Treatment and Prognosis Analysis of Small Cell Breast Carcinoma: A Population-Based Study.Frontiers in endocrinology · 2022Trial
- Primary Small Cell Neuroendocrine Carcinoma of the Sublingual Gland Treated With Definitive Chemoradiotherapy: A Case Report.Clinical case reports · 2026Article
- Association of surgery with survival in small cell carcinoma of the digestive system: a population-based observational study using machine learning.Scientific reports · 2026Observational
- A complete pathological response to preoperative chemotherapy in a male patient with primary neuroendocrine breast cancer: a case report.Journal of medical case reports · 2026Article
- Mammary small cell neuroendocrine carcinomas that showed excellent pathologic response following etoposide-based neoadjuvant chemotherapy.Breast cancer research and treatment · 2025Article
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- Article
- Localized Colonic Small-Cell Carcinoma with Pathological Complete Response after Neoadjuvant Cisplatin and Etoposide: A Case Report.Current oncology (Toronto, Ont.) · 2023Article
- Small-cell neuroendocrine carcinoma of the rectum - a rare tumor type with poor prognosis: A case report and review of literature.World journal of clinical cases · 2020Article
- Comparison of treatment strategies for patients with limited-stage small cell lung cancer who received chemotherapy.Translational cancer research · 2020Article
- Primary small-cell carcinoma of the palate - the second case report worldwide.Archives of medical science : AMS · 2017Article
- Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases.Case reports in otolaryngology · 2017Article
- Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2015Review
- A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992-2010.BMC cancer · 2015Article
- A population-based analysis of outcomes for small cell carcinoma of the breast by tumor stage and the use of radiation therapy.SpringerPlus · 2015Article
- The 2002 AJCC TNM classification is a better predictor of primary small cell esophageal carcinoma outcome than the VALSG staging system.Chinese journal of cancer · 2013Article
- Optimizing of the tangential technique and supraclavicular fields in 3 dimensional conformal radiation therapy for breast cancer.Journal of medical signals and sensors · 2013Article
- Optimal management of extra-pulmonary small cell carcinoma and the role of prophylactic cranial irradiation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2012Article
- Cerebral metastases in extrapulmonary cell carcinoma. Implications for the use of prophylactic cranial irradiation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesExtrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC.
methodsThe Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy.
resultsWe identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival.
conclusionsAlthough outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.
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