ArticleThe Journal of comparative neurology2011
Subcellular localization of Patched and Smoothened, the receptors for Sonic hedgehog signaling, in the hippocampal neuron.
Article in The Journal of comparative neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management.iScience · 2026Article
- Neuronal guidance behaviours: the primary cilium perspective.Frontiers in cell and developmental biology · 2025Review
- Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols.Frontiers in cell and developmental biology · 2025Article
- A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.Cell reports · 2022Article
- Ciliary signaling proteins are mislocalized in the brains of Bardet-Biedl syndrome 1-null mice.Frontiers in cell and developmental biology · 2022Article
- Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior.Neurochemical research · 2021Review
- Sonic hedgehog signaling in astrocytes.Cellular and molecular life sciences : CMLS · 2021Review
- Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain.Frontiers in physiology · 2021Review
- Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex.Journal of cell science · 2020Article
- Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.Frontiers in pharmacology · 2020Article
- Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus.Frontiers in cellular neuroscience · 2020Article
- Sonic hedgehog enhances calcium oscillations in hippocampal astrocytes.The Journal of biological chemistry · 2019Article
- Sonic hedgehog expression in the postnatal brain.Biology open · 2019Article
- The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.Molecular psychiatry · 2018Article
- Invaginating Structures in Mammalian Synapses.Frontiers in synaptic neuroscience · 2018Review
- High frequency stimulation induces sonic hedgehog release from hippocampal neurons.Scientific reports · 2017Article
- Sonic -'Jack-of-All-Trades' in Neural Circuit Formation.Journal of developmental biology · 2017Review
- Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons.Molecular biology of the cell · 2017Article
- The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease.Journal of developmental biology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cumulative evidence suggests that, aside from patterning the embryonic neural tube, Sonic hedgehog (Shh) signaling plays important roles in the mature nervous system. In this study, we investigate the expression and localization of the Shh signaling receptors, Patched (Ptch) and Smoothened (Smo), in the hippocampal neurons of young and mature rats. Reverse transcriptase-polymerase chain reaction and immunoblotting analyses show that the expression of Ptch and Smo remains at a moderate level in young postnatal and adult brains. By using immunofluorescence light microscopy and immunoelectron microscopy, we examine the spatial distribution of Ptch and Smo within the hippocampal neurons. In young developing neurons, Ptch and Smo are present in the processes and are clustered at their growth cones. In mature neurons, Ptch and Smo are concentrated in dendrites, spines, and postsynaptic sites. Synaptic Ptch and Smo often co-exist with unusual structures-synaptic spinules and autophagosomes. Our results reveal the anatomical organization of the Shh receptors within both the young and the mature hippocampal neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.