SynthesisIrish journal of medical science2011
Soothing a sore throat: the efficacy and safety of steroids in acute pharyngitis.
Synthesis in Irish journal of medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Corticosteroids as standalone or add-on treatment for sore throat.The Cochrane database of systematic reviews · 2020Pooled it
- Review
- Multi-pathway integrated adjustment mechanism of licorice flavonoids presenting anti-inflammatory activity.Oncology letters · 2019Article
- Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2/COX-2 expression.Saudi journal of biological sciences · 2018Article
- Anti-inflammatory activity of Yanshu spraying agent in animal models.Experimental and therapeutic medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute pharyngitis is a common presentation to Emergency Departments (EDs) and although most patients experience mild-to-moderate discomfort, severe pharyngitis can be incapacitating and painful. There have been recent trends in prescribing steroids to provide pain relief for patients with acute pharyngitis.
aimTo examine the evidence for using steroids in adult patients with acute pharyngitis attending Emergency Departments.
methodsA comprehensive literature search was performed to identify randomised controlled trials, systematic reviews and meta-analyses. The primary outcome measure assessed was pain relief, while safety of steroids was chosen as a secondary outcome measure.
resultsSix papers met the inclusion criteria--five randomised controlled clinical trials and one systematic review (adult and paediatric patients in a variety of clinical settings). Mean times to onset of pain relief were shorter in patients receiving steroids (8.1 vs. 19.9 h, 6.3 vs. 11.3 h, 6.3 vs. 12.4 h). A single study examining reduction in VAS pain scores found a statistically significant improvement in patients given steroids (PO: 4.2 ± 2.3, IM: 3.8 ± 2.3 vs placebo: 2.0). Marvez-Valls et al. reported shorter times to complete pain relief (43 vs. 36 h) but this and other studies failed to demonstrate a statistically significant reduction in the pain scores at 24 h. Frequency and nature of side effect reporting was inconsistent throughout the studies with no trials explicitly powered to detect clinically important adverse events.
conclusionSteroids may provide a useful adjunct in the management of acute pharyngitis, but there is currently insufficient evidence to endorse routine use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.