ArticleJournal of clinical gastroenterology
Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma.
Article in Journal of clinical gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.Alimentary pharmacology & therapeutics · 2021Pooled it
- VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus.Nature communications · 2026Article
- Endoscopic Screening of Barrett's Esophagus.Gastrointestinal endoscopy clinics of North America · 2026Review
- Pediatric unsedated transnasal endoscopy: applications, equipment, and future directions.Frontiers in pediatrics · 2025Review
- Identification ofDiagnostics (Basel, Switzerland) · 2024Article
- Diagnosis and Management of Barrett's Esophagus.Journal of clinical medicine · 2023Review
- Barrett's Oesophagus: Today's Mistake and Tomorrow's Wisdom in Screening and Prevention.Visceral medicine · 2022Review
- Endoscopic Screening for Barrett's Esophagus and Esophageal Adenocarcinoma: Rationale, Candidates, and Challenges.Gastrointestinal endoscopy clinics of North America · 2021Review
- Recent Advances in Screening for Barrett's Esophagus.Current treatment options in gastroenterology · 2018Review
- Precision care for Barrett's esophagus.Translational gastroenterology and hepatology · 2018Review
- Screening and Preventive Strategies in Esophagogastric Cancer.Surgical oncology clinics of North America · 2017Review
- Risk Factors for Barrett's Oesophagus.Gastrointestinal tumors · 2016Review
- Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Predictors of Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett's Esophagus.Gastroenterology clinics of North America · 2015Review
- Screening for Barrett's Esophagus.Gastroenterology · 2015Review
- Screening for Barrett's esophagus and esophageal adenocarcinoma: rationale, recent progress, challenges, and future directions.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Review
- Barrett's esophagus and cancer risk: how research advances can impact clinical practice.Gut and liver · 2014Review
- Operable gastro-oesophageal junctional adenocarcinoma: Where to next?World journal of gastrointestinal oncology · 2014Review
- Hereditary Factors in Esophageal Adenocarcinoma.Gastrointestinal tumors · 2014Review
- Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study.BMC cancer · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
aimThe aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD).
methodsAfter Institutional Review Board approval, first-degree relatives of patients with EAC/HGD underwent unsedated ultrathin transnasal endoscopy (UUTNE) with biopsy. BE was suspected if any salmon-colored epithelial tongues were seen above the gastroesophageal junction. A diagnosis of BE was made only if biopsy from these areas confirmed columnar-lined epithelium with intestinal metaplasia.
resultsFrom 23 families, 47 first-degree relatives underwent ultrathin transnasal endoscopy and 1 patient underwent routine upper endoscopy with sedation as part of this study. The mean age of cases was 44.4 years. All patients tolerated the procedure well and there were no procedure-related complications. BE was suspected in 16 (34%) patients and confirmed in 13 of 16 (27.7%) patients. There were 4 long segments (>3 cm) and 9 short segments (<3 cm) of BE.
conclusionThere is a significantly higher than expected prevalence of BE in first-degree relatives of patients with EAC/HGD. This should be taken in to consideration to develop further screening guidelines. Further work is needed to confirm these findings. Unsedated transnasal endoscopy is a safe and well-tolerated method for BE screening.
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Registered trials
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