ArticleEpigenetics2011
The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood.
Article in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.Clinical epigenetics · 2017Trial
- DNA methylation is associated with hair trace elements in female adolescents from two vulnerable populations in the Colombian Caribbean.Environmental epigenetics · 2024Article
- BCurve: Bayesian Curve Credible Bands Approach for the Detection of Differentially Methylated Regions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- An Exploratory Pilot Study of Changes in Global DNA Methylation in Patients Undergoing Major Breast Surgery Under Opioid-Based General Anesthesia.Frontiers in pharmacology · 2021Article
- Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease.International journal of molecular sciences · 2020Review
- Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overview.Cellular and molecular life sciences : CMLS · 2018Review
- The Biosocial Approach to Human Development, Behavior, and Health Across the Life Course.The Russell Sage Foundation journal of the social sciences : RSF · 2018Article
- DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity.Lupus science & medicine · 2018Article
- Critical Issues in the Inclusion of Genetic and Epigenetic Information in Prevention and Intervention Trials.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.Frontiers in genetics · 2018Article
- DNA methylation signature of human fetal alcohol spectrum disorder.Epigenetics & chromatin · 2016Article
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?Clinical epigenetics · 2015Article
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Influence of environmental exposure on human epigenetic regulation.The Journal of experimental biology · 2015Review
- Association of DNA methylation with age, gender, and smoking in an Arab population.Clinical epigenetics · 2015Article
- Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth.Epigenetics · 2014Article
- An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.The Journal of investigative dermatology · 2014Article
- Genetic and epigenetic predictors of responsiveness to treatment in RA.Nature reviews. Rheumatology · 2014Review
- Associations between serum perfluoroalkyl acids and LINE-1 DNA methylation.Environment international · 2014Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
In order to properly comprehend the epigenetic dysregulation that occurs during the course of disease, there is a need to characterize the epigenetic variability in healthy individuals that arises in response to aging and exposures, and to understand such variation within the biological context of the DNA sequence. We analyzed the methylation of 26,486 autosomal CpG loci in blood from 205 healthy subjects, using three complementary approaches to assess the association between methylation, age or exposures, and local sequence features, such as CpG island status, repeat sequences, location within a polycomb target gene or proximity to a transcription factor binding site. We clustered CpGs (1) using unsupervised recursively partitioned mixture modeling (RPMM) and (2) bioinformatically-informed methods, and (3) also employed a marginal model-based (non-clustering) approach. We observed associations between age and methylation and hair dye use and methylation, where the direction and magnitude was contingent on the local sequence features of the CpGs. Our results demonstrate that CpGs are differentially methylated dependent upon the genomic features of the sequence in which they are embedded, and that CpG methylation is associated with age and hair dye use in a CpG context-dependent manner in healthy individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.