ArticleAmerican journal of respiratory cell and molecular biology2011
Polycyclic aromatic hydrocarbons impair function of β2-adrenergic receptors in airway epithelial and smooth muscle cells.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Moving beyond medication: Assessment and interventions on environmental and social determinants are needed to reduce severe asthma.The Journal of allergy and clinical immunology · 2022Article
- Nasal DNA methylation differentiates severe from non-severe asthma in African-American children.Allergy · 2021Article
- Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases.Respiratory research · 2020Review
- Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases.Current opinion in pharmacology · 2020Review
- Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma.Environmental geochemistry and health · 2019Review
- Molecular characterization of G-protein-coupled receptor (GPCR) and protein kinase A (PKA) cDNA inPeerJ · 2019Article
- Pro-inflammatory effects of extracted urban fine particulate matter on human bronchial epithelial cells BEAS-2B.Environmental science and pollution research international · 2018Article
- Benzo(a)pyrene triggers desensitization of β2-adrenergic pathway.Scientific reports · 2017Article
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring.Journal of toxicology · 2013Article
- Dietary factors associated with lifetime asthma or hayfever diagnosis in Australian middle-aged and older adults: a cross-sectional study.Nutrition journal · 2012Article
- Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Incomplete combustion produces a pollutant mixture that includes polycyclic aromatic hydrocarbons (PAHs). Previous work by the Columbia Center for Children's Environmental Health (CCCEH) and others linked exposure to PAH with symptoms of asthma and other adverse health effects in young children. Inhaled β(2)-adrenergic agonists are mainstays in the treatment of reactive airway diseases. These exogenous catecholamines engage membrane-bound β(2)-adrenergic receptors (β(2)AR) on airway epithelial and smooth muscle cells to cause airway dilation. We hypothesized that exposure to PAH might similarly interfere with the function of β(2)AR in airway epithelial or smooth muscle cells, reducing the efficacy of a medication important for the treatment of asthma symptoms. A PAH mixture was devised, based on ambient levels measured prenatally among a cohort of pregnant women participating at the CCCEH. Primary airway epithelial and smooth muscle cells were exposed to varying concentrations of the PAH mixture, and expression, function, and signaling of β(2)AR were assessed. Murine tracheal epithelial cells and human airway smooth muscle cells, after exposure to a PAH mixture, exhibited reduced expression and function of β(2)AR. These findings support our hypothesis that environmentally relevant PAHs can impede β(2)AR-mediated airway relaxation, and suggest a new paradigm where air pollutants not only contribute to the pathogenesis of childhood asthma, but also diminish responsiveness to standard therapy.
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