Evidence map›Paper›PMID 21616670›Full record

ReviewTrends in biochemical sciences2011

Mass spectrometry accelerates membrane protein analysis.

Jeffrey N Savas, Benjamin D Stein, Christine C Wu, John R Yates

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Exosome Proteomics of SOD1Annals of clinical and translational neurology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Emergence of mass spectrometry detergents for membrane proteomics.Analytical and bioanalytical chemistry · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Cell Surface Biotinylation Using Furan Cross-Linking Chemistry.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  13. Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Large-Scale Phosphoproteomic Study ofInternational journal of molecular sciences · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jeffrey N SavasDepartment of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Benjamin D Stein
Christine C Wu
John R Yates
Scripps Research Institute · USUniversity of Pittsburgh · US

Funding

ZDS2P REGULATES SWE1P-DEPENDENT POLARIZED CELL GROWTH IN S CEREVISIAEP41RR011823 · NCRR · UNIVERSITY OF WASHINGTON · PI FIELDS, STANLEY · 1996 to 2011
$24.7M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Quantitative Proteome Analysis of Brain DevelopmentR01MH067880 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2003 to 2017
$7.1M
Proteomic Profiling of CFTR Protein InteractionR01HL079442 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI BALCH, WILLIAM EDWARD, YATES III, JOHN R · 2005 to 2014
$4.6M
NCRR NIH HHS P41 RR011823NHLBI NIH HHS R01 HL079442NIGMS NIH HHS P41 GM103533NIMH NIH HHS 5R01 MH067880NIMH NIH HHS R01 MH067880
6 · The paper itself

Abstract

Cellular membranes are composed of proteins and glyco- and phospholipids and play an indispensible role in maintaining cellular integrity and homeostasis, by physically restricting biochemical processes within cells and providing protection. Membrane proteins perform many essential functions, which include operating as transporters, adhesion-anchors, receptors, and enzymes. Recent advancements in proteomic mass spectrometry have resulted in substantial progress towards the determination of the plasma membrane (PM) proteome, resolution of membrane protein topology, establishment of numerous receptor protein complexes, identification of ligand-receptor pairs, and the elucidation of signaling networks originating at the PM. Here, we discuss the recent accelerated success of discovery-based proteomic pipelines for the establishment of a complete membrane proteome.

Indexed as

AnimalsCell MembraneHumansMass SpectrometryMembrane ProteinsProteomicsMembrane Proteins

Identifiers

PMID21616670
PMCPMC3222592
OpenAlexW2114949268

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.