ArticleCell calcium2011
Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs.
Article in Cell calcium, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A mechanism of lysosomal calcium entry.Science advances · 2024Article
- Role of GABAFrontiers in cellular neuroscience · 2022Article
- Termination of CaCell calcium · 2021Article
- The role of ATP in the differential ability of Sr2+ to trigger Ca2+ oscillations in mouse and human eggs.Molecular human reproduction · 2021Article
- ER-luminal [CaeLife · 2020Article
- High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder.Scientific reports · 2017Article
- Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors.Journal of molecular neuroscience : MN · 2015Review
- Differential Regulation of Multiple Steps in Inositol 1,4,5-Trisphosphate Signaling by Protein Kinase C Shapes Hormone-stimulated Ca2+ Oscillations.The Journal of biological chemistry · 2015Article
- Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Cytosolic [Ca2+] regulation of InsP3-evoked puffs.The Biochemical journal · 2013Article
- Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.The Journal of general physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Liberation of Ca(2+) from the endoplasmic reticulum (ER) through inositol trisphosphate receptors (IP(3)R) is modulated by the ER Ca(2+) content, and overexpression of SERCA2b to accelerate Ca(2+) sequestration into the ER has been shown to potentiate the frequency and amplitude of IP(3)-evoked Ca(2+) waves in Xenopus oocytes. Here, we examined the effects of SERCA overexpression on the elementary IP(3)-evoked puffs to elucidate whether ER [Ca(2+)] may modulate IP(3)R function via luminal regulatory sites in addition to simply determining the size of the available store and electrochemical driving force for Ca(2+) release. SERCA2b and Ca(2+) permeable nicotinic plasmalemmal channels were expressed in oocytes, and hyperpolarizing pulses were delivered to induce Ca(2+) influx and thereby load ER stores. Puffs evoked by photoreleased IP(3) were significantly potentiated in terms of numbers of responding sites, frequency and amplitude following transient Ca(2+) influx in SERCA-overexpressing cells, whereas little change was evident with SERCA overexpression alone or following Ca(2+) influx in control cells not overexpressing SERCA. Intriguingly, we observed the appearance of a new population of puffs that arose after long latencies and had prolonged durations supporting the notion of luminal regulation of IP(3)R gating kinetics.
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