ArticleBiochemical and biophysical research communications2011
Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.
Article in Biochemical and biophysical research communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- UBC-9 Acts in GABA Neurons to Control Neuromuscular Signaling inNeuroscience insights · 2020Article
- Response: Commentary: Analysis of SUMO1-conjugation at synapses.Frontiers in cellular neuroscience · 2018Article
- Analysis of SUMO1-conjugation at synapses.eLife · 2017Article
- Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP ConsolidationFrontiers in synaptic neuroscience · 2017Article
- SUMOylation of Argonaute-2 regulates RNA interference activity.Biochemical and biophysical research communications · 2015Article
- Receptor trafficking and the regulation of synaptic plasticity by SUMO.Neuromolecular medicine · 2013Review
- Protein sumoylation in brain development, neuronal morphology and spinogenesis.Neuromolecular medicine · 2013Review
- SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons.PloS one · 2013Article
- In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Homeostatic synaptic scaling is regulated by protein SUMOylation.The Journal of biological chemistry · 2012Article
- Protein SUMOylation in spine structure and function.Current opinion in neurobiology · 2012Review
- Regulation of Neuronal Protein Trafficking and Translocation by SUMOylation.Biomolecules · 2012Article
- Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
G-protein coupled receptor interacting scaffold protein (GISP) is a multi-domain, brain-specific protein derived from the A-kinase anchoring protein (AKAP)-9 gene. Using yeast two-hybrid screens to identify GISP interacting proteins we isolated the SUMO conjugating enzyme Ubc9. GISP interacts with Ubc9 in vitro, in heterologous cells and in neurons. SUMOylation is a post-translational modification in which the small protein SUMO is covalently conjugated to target proteins, modulating their function. Consistent with its interaction with Ubc9, we show that GISP is SUMOylated by both SUMO-1 and SUMO-2 in both in vitro SUMOylation assays and in mammalian cells. Intriguingly, SUMOylation of GISP in neurons occurs in an activity-dependent manner in response to chemical LTP. These data suggest that GISP is a novel neuronal SUMO substrate whose SUMOylation status is modulated by neuronal activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.