Evidence map›Paper›PMID 21615922›Full record

ArticleCardiovascular diabetology2011

Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction.

Vera B Schrauwen-Hinderling, Ruth C R Meex, Matthijs K C Hesselink, Tineke van de Weijer, Tim Leiner, Michael Schär, Hildo J Lamb, Joachim E Wildberger, Jan F C Glatz, Patrick Schrauwen and 1 more

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In one paragraph

Article in Cardiovascular diabetology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  15. Non-Water-SuppressedScientific reports · 2017 · on this map
    Article
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  17. La Radiologia medica · 2017
    Article
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  19. The Flexibility of Ectopic Lipids.International journal of molecular sciences · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Vera B Schrauwen-HinderlingNUTRIM, School of Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands. v.schrauwen@maastrichtuniversity.nl
Ruth C R Meex
Matthijs K C Hesselink
Tineke van de Weijer
Tim Leiner
Michael Schär
Hildo J Lamb
Joachim E Wildberger
Jan F C Glatz
Patrick Schrauwen
M Eline Kooi
Maastricht University · NLLeiden University Medical Center · NLMaastricht University Medical Centre · NLMonash University · AUPhilips (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased cardiac lipid content has been associated with diabetic cardiomyopathy. We recently showed that cardiac lipid content is reduced after 12 weeks of physical activity training in healthy overweight subjects. The beneficial effect of exercise training on cardiovascular risk is well established and the decrease in cardiac lipid content with exercise training in healthy overweight subjects was accompanied by improved ejection fraction. It is yet unclear whether diabetic patients respond similarly to physical activity training and whether a lowered lipid content in the heart is necessary for improvements in cardiac function. Here, we investigated whether exercise training is able to lower cardiac lipid content and improve cardiac function in type 2 diabetic patients.

methodsEleven overweight-to-obese male patients with type 2 diabetes mellitus (age: 58.4 ± 0.9 years, BMI: 29.9 ± 0.01 kg/m2) followed a 12-week training program (combination endurance/strength training, three sessions/week). Before and after training, maximal whole body oxygen uptake (VO2max) and insulin sensitivity (by hyperinsulinemic, euglycemic clamp) was determined. Systolic function was determined under resting conditions by CINE-MRI and cardiac lipid content in the septum of the heart by Proton Magnetic Resonance Spectroscopy.

resultsVO2max increased (from 27.1 ± 1.5 to 30.1 ± 1.6 ml/min/kg, p = 0.001) and insulin sensitivity improved upon training (insulin stimulated glucose disposal (delta Rd of glucose) improved from 5.8 ± 1.9 to 10.3 ± 2.0 μmol/kg/min, p = 0.02. Left-ventricular ejection fraction improved after training (from 50.5 ± 2.0 to 55.6 ± 1.5%, p = 0.01) as well as cardiac index and cardiac output. Unexpectedly, cardiac lipid content in the septum remained unchanged (from 0.80 ± 0.22% to 0.95 ± 0.21%, p = 0.15).

conclusionsTwelve weeks of progressive endurance/strength training was effective in improving VO2max, insulin sensitivity and cardiac function in patients with type 2 diabetes mellitus. However, cardiac lipid content remained unchanged. These data suggest that a decrease in cardiac lipid content in type 2 diabetic patients is not a prerequisite for improvements in cardiac function.

trial registrationISRCTN: ISRCTN43780395.

Indexed as

Lipid MetabolismResistance TrainingStroke VolumeVentricular Function, LeftAdiposityBody WeightDiabetes Mellitus, Type 2Diabetic CardiomyopathiesGlucose Clamp TechniqueHumansInsulin ResistanceMagnetic Resonance Imaging, CineMagnetic Resonance SpectroscopyMaleMiddle AgedMyocardium

Identifiers

PMID21615922
PMCPMC3127755
OpenAlexW2111398433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.