ArticleJournal of veterinary internal medicine
In vitro lysis and acute transfusion reactions with hemolysis caused by inappropriate storage of canine red blood cell products.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Comparative effects of syngeneic graft and xenograft blood for hemolytic anemia modeling in dogs.Open veterinary journal · 2026Article
- Understanding the biochemical impact of leukoreduction on canine pRBC storage: a focus on reactive oxygen species and storage lesions.Frontiers in veterinary science · 2025Article
- Sudden Cardiac Death due to Ventricular Fibrillation in a Dog Following Packed Red Blood Cell Transfusion.Case reports in veterinary medicine · 2025Article
- Crossmatch: Alloimmunization versus unspecific agglutination reactions?Journal of veterinary internal medicine · 2023Article
- Effect of microaggregate filter passage on feline whole blood stored for 35 days.Journal of feline medicine and surgery · 2022Article
- Effect of washing units of canine red blood cells on storage lesions.Journal of veterinary internal medicine · 2022Article
- Comparison of four different hematocrit assays and the effect of albumin on their measurements.Frontiers in veterinary science · 2022Article
- Red blood cell osmotic fragility in healthy loggerhead and green sea turtles.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Prospective Comparative Quality Control Study of a Novel Gravity-Driven Hollow-Fiber Whole Blood Separation System for the Production of Canine Blood Products.Frontiers in veterinary science · 2019Article
- Visual inspection of stored canine blood for hemolysis compared with measured plasma-free hemoglobin to assess suitability for transfusion.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- In vitro quality control analysis after processing and during storage of feline packed red blood cells units.BMC veterinary research · 2018Article
- Xenotransfusion of anemic cats with blood compatibility issues: pre- and posttransfusion laboratory diagnostic and crossmatching studies.Veterinary clinical pathology · 2016Article
- The effectiveness of cooling conditions on temperature of canine EDTA whole blood samples.PeerJ · 2016Article
- DEA 1 expression on dog erythrocytes analyzed by immunochromatographic and flow cytometric techniques.Journal of veterinary internal medicineArticle
- Effect of duration of packed red blood cell storage on morbidity and mortality in dogs after transfusion: 3,095 cases (2001-2010).Journal of veterinary internal medicineArticle
- Development and Evaluation of a PCV-Dependent Visual Hemolysis Color Scale for Packed Red Blood Cell Products.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTransfusion of red blood cell (RBC) products carries considerable risk for adverse reactions, including life-threatening hemolytic reactions.
objectiveTo report the occurrence and investigation of life-threatening acute transfusion reactions with hemolysis in dogs likely related to inappropriate blood product storage. ANIMALS: Four dogs with acute transfusion reactions and other recipients of blood products.
methodsMedical records were reviewed from 4 dogs with suspected acute hemolytic transfusion reactions after receiving RBC products at a veterinary clinic over a 1-month period. Medical records of other animals receiving blood products in the same time period also were reviewed. Blood compatibility and product quality were assessed, subsequent transfusions were closely monitored, and products were diligently audited.
resultsDuring or immediately after RBC product transfusion, 4 dogs developed hemolysis, hemoglobinuria, or both. Two dogs died and 1 was euthanized because of progressive clinical signs compatible with an acute hemolytic transfusion reaction. Blood type and blood compatibility were confirmed. RBC units from 2 blood banks were found to be hemolyzed after storage in the clinic's refrigerator; no bacterial contamination was identified. After obtaining a new refrigerator dedicated to blood product storage, the problem of hemolyzed units and acute transfusion reactions with hemolysis completely resolved.
conclusionsAcute life-threatening transfusion reactions can be caused by inappropriate storage of RBC products. In addition to infectious disease screening and ensuring blood-type compatibility, quality assessment of blood products, appropriate collection, processing, and storage techniques as well as recipient monitoring are critical to provide safe, effective transfusions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.