ReviewProtein & cell2011
Thyroid hormone action in metabolic regulation.
Review in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans.Journal of lipid research · 2014Trial
- Clinical and metabolic links between hypothyroidism and metabolic syndrome: a review.Frontiers in endocrinology · 2026Review
- Lack of difference in thyroid hormone profile between offspring conceived naturally and through ART.Human reproduction open · 2026Article
- A Rare Endocrinological Emergency in Children with Hypothyroidism: Clinical Evaluation of Cases Presenting with Myxedema Coma.Turkish archives of pediatrics · 2025Article
- When Should the Treatment of Obesity in Thyroid Disease Begin?Biomedicines · 2025Review
- The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue.International journal of molecular sciences · 2024Article
- Associations between peripheral thyroid sensitivity and all-cause and cardiovascular mortality in the US adults with metabolic syndrome.Frontiers in medicine · 2024Article
- Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases.Frontiers in molecular biosciences · 2023Review
- The Myxedema coma in children and adolescents: A rare endocrine emergency - Personal experience and review of literature.Acta bio-medica : Atenei Parmensis · 2021Review
- Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax.Frontiers in zoology · 2020Article
- Role of irisin in Chinese patients with hypothyroidism: an interventional study.The Journal of international medical research · 2019Article
- Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism.BMC endocrine disorders · 2019Article
- Levothyroxine Replacement Alleviates Thyroid Destruction in Hypothyroid Patients With Autoimmune Thyroiditis: Evidence From a Thyroid MRI Study.Frontiers in endocrinology · 2019Article
- A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations.Molecular medicine reports · 2018Article
- Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats.The journal of physiological sciences : JPS · 2018Article
- Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.International journal of molecular sciences · 2018Review
- Role of microRNA in metabolic shift during heart failure.American journal of physiology. Heart and circulatory physiology · 2017Review
- Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1).The Journal of biological chemistry · 2014Article
- Atom-based 3D-QSAR, molecular docking and molecular dynamics simulation assessment of inhibitors for thyroid hormone receptor α and β.Journal of molecular modeling · 2014Article
- Role of nuclear receptors in blastocyst implantation.Seminars in cell & developmental biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone plays pivotal roles in growth, differentiation, development and metabolic homeostasis via thyroid hormone receptors (TRs) by controlling the expression of TR target genes. The transcriptional activity of TRs is modulated by multiple factors including various TR isoforms, diverse thyroid hormone response elements, different heterodimeric partners, coregulators, and the cellular location of TRs. In the present review, we summarize recent advance in understanding the molecular mechanisms of thyroid hormone action obtained from human subject research, thyroid hormone mimetics application, TR isoform-specific knock-in mouse models, and mitochondrion study with highlights in metabolic regulations. Finally, as future perspectives, we share our thoughts about current challenges and possible approaches to promote our knowledge of thyroid hormone action in metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.