ArticlePharmaceutical research2011
Epithelial profiling of antibiotic controlled release respiratory formulations.
Article in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Research on the preparation of antimicrobial material based on thermoplastic polyurethane and drug release control.Drug delivery and translational research · 2025Article
- A Dynamic Breathing Lung Chip for Precise Evaluation of Inhaled Drug Efficacy and Airway Epithelial Responses.ACS biomaterials science & engineering · 2025Article
- In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells.Journal of Taibah University Medical Sciences · 2023Article
- In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model.International journal of pharmaceutics · 2021Article
- Modifying and IntegratingFrontiers in bioengineering and biotechnology · 2020Review
- Evaluation of co-delivery of colistin and ciprofloxacin in liposomes using an in vitro human lung epithelial cell model.International journal of pharmaceutics · 2019Article
- Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study.Pharmaceutics · 2018Article
- Sweetening Inhaled Antibiotic Treatment for Eradication of Chronic Respiratory Biofilm Infection.Pharmaceutical research · 2018Article
- Biological Effects of Simvastatin Formulated as pMDI on Pulmonary Epithelial Cells.Pharmaceutical research · 2016Article
- Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases.The AAPS journal · 2014Article
- Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2014Article
- Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model.Antimicrobial agents and chemotherapy · 2013Article
- Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia.Pharmaceutical research · 2012Article
- Modification of disodium cromoglycate passage across lung epithelium in vitro via incorporation into polymeric microparticles.The AAPS journal · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRelease profiles of two ciprofloxacin hydrochloride formulations for the treatment of respiratory infection were evaluated using different in vitro methodologies and characterised for aerosol performance and toxicity.
methodsSpray-dried ciprofloxacin and ciprofloxacin spray-dried with polyvinyl alcohol as a controlled release (CR) agent at a 50:50 w/w ratio were formulated and physico-chemically characterised. Aerosol performances were assessed in vitro using a liquid impinger. Drug release was performed using a modified Franz cell and a validated air interface Calu-3-modified twin stage impinger (TSI). Ciprofloxacin toxicity was also established in vitro.
resultsBoth formulations had a similar size distribution, while CR ciprofloxacin had superior aerosol performance and stability. The release profiles showed the CR formulation to have a higher transport rate compared to ciprofloxacin alone in the cell model. Contrary results were observed using the diffusion cell. Results suggest that the air interface cell model provides a more physiologically relevant model than the modified Franz cell. Toxicity analysis showed that the lung epithelial cells could tolerate a wide range of ciprofloxacin concentrations.
conclusionsThis study establishes that the in vitro modified TSI air interface Calu-3 model is capable of evaluating the fate of inhaled powder formulations.
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