Evidence map›Paper›PMID 21614582›Full record

ArticleImmunogenetics2011

Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques.

Hannah M Creager, Ericka A Becker, Kelly K Sandman, Julie A Karl, Simon M Lank, Benjamin N Bimber, Roger W Wiseman, Austin L Hughes, Shelby L O'Connor, David H O'Connor

Abstract read
In one paragraph

Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannah M CreagerWisconsin National Primate Research Center, University of Wisconsin-Madison, USA.
Ericka A Becker
Kelly K Sandman
Julie A Karl
Simon M Lank
Benjamin N Bimber
Roger W Wiseman
Austin L Hughes
Shelby L O'Connor
David H O'Connor

Funding

ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
Immunogenetics of Primates Used for Bioterror ResearchR24RR021745 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2005 to 2011
$3.3M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
Immunogenetics of Macaques Used for Biodefense and AIDS ResearchR24OD011048 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2012 to 2013
$1.1M
NCRR NIH HHS 1 R24 RR021745-01A1NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NCRR NIH HHS P51 RR000167NCRR NIH HHS R24 RR021745NCRR NIH HHS RR020141-0NCRR NIH HHS RR15459-01NIH HHS R24 OD011048
6 · The paper itself

Abstract

In recent years, the use of cynomolgus macaques in biomedical research has increased greatly. However, with the exception of the Mauritian population, knowledge of the MHC class II genetics of the species remains limited. Here, using cDNA cloning and Sanger sequencing, we identified 127 full-length MHC class II alleles in a group of 12 Indonesian and 12 Vietnamese cynomolgus macaques. Forty two of these were completely novel to cynomolgus macaques while 61 extended the sequence of previously identified alleles from partial to full length. This more than doubles the number of full-length cynomolgus macaque MHC class II alleles available in GenBank, significantly expanding the allele library for the species and laying the groundwork for future evolutionary and functional studies.

Indexed as

AnimalsBase SequenceGenes, MHC Class IIIndonesiaMacaca fascicularisMolecular Sequence DataVietnam

Identifiers

PMID21614582
PMCPMC3156323

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.